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Literature DB >> 8620940

The action of the cholecystokinin-A receptor antagonist, devazepide, on the digestive system of the chicken.

M Furuse¹, Y H Choi, S Satoh, J Okumura.

Abstract

The influence of the cholecystokinin (CCK)-A receptor antagonist, devazepide (DVZ), on the chicken digestive tract was investigated. The passage of food from the crops of birds treated with DVZ was not significantly different from that of the control. DVZ treatment did not inhibit the biliary flow stimulated by the CCK analogue, caerulein. Dispersed chicken pancreatic acini stimulated with CCK were treated with various concentrations of DVZ. At 10-5 M, DVZ completely inhibited amylase release; this concentration was much higher than those reported to have similar effects in mammals. The results suggest that the action DVZ as a CCK antagonist in the chicken is very weak.

Entities: Chemical Disease Gene Species

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Year: 1996 PMID： 8620940 DOI： 10.1007/bf01919540

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

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References

16 in total

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Authors: R Bruzzone; P A Halban; A Gjinovci; E R Trimble
Journal: Biochem J Date: 1985-03-01 Impact factor: 3.857

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Authors: R Dimaline; J Young; H Gregory
Journal: FEBS Lett Date: 1986-09-15 Impact factor: 4.124

The action of the cholecystokinin-A receptor antagonist, devazepide, on the digestive system of the chicken.

1. A new, rapid, method for preparation of dispersed pancreatic acini.

2. Isolation from chicken antrum, and primary amino acid sequence of a novel 36-residue peptide of the gastrin/CCK family.

Review 3. Molecular evolution of gut hormones: application of comparative studies on the regulation of digestion.

4. A new method for the determination of alpha-amylase.

5. Feeding behavior in rats fed diets containing medium chain triglyceride.

6. A single amino acid of the cholecystokinin-B/gastrin receptor determines specificity for non-peptide antagonists.

7. Hormonal control of avian pancreas by gastrin-releasing peptide from the proventriculus.

8. Endogenous cholecystokinin reduces feeding in young rats.

9. Effect of L364718, a new CCK antagonist, on amylase secretion in isolated rat pancreatic acini.

10. Cholecystokinin is not a major regulator in the digestive system in the chicken.