| Literature DB >> 2321020 |
A Weller1, G P Smith, J Gibbs.
Abstract
The hypothesis that endogenous cholecystokinin (CCK) released from the small intestine during feeding causes satiety was tested in rat pups, 9 to 12 days old. Intragastric administration of soybean trypsin inhibitor, a procedure that releases CCK from the small intestine, decreased the subsequent intake of a test meal. This effect was reversed by prior treatment with MK-329, a selective antagonist of CCK at alimentary-type CCK (CCK-A) receptors. Thus, endogenous, small intestinal CCK can cause satiety in the neonatal rat and this effect involves CCK-A receptors.Entities:
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Year: 1990 PMID： 2321020 DOI： 10.1126/science.2321020
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728