Literature DB >> 861164

Portacaval transposition and subsequent partial hepatectomy in the rat: effects on liver atrophy, hypertrophy and regenerative hyperplasia.

J Guest, C J Ryan, I S Benjamin, L H Blumgart.   

Abstract

Portacaval transposition diverts portal blood from the liver. It allows systemic venous blood to perfuse the portal bed. Body weight and liver weight have been followed before and after portacaval transposition and control procedures in rats, and the DNA activity ratio studied in the liver of rats after partial hepatectomy in protacavally transposed animals. The results suggest that the liver atrophy seen after portal diversion is a result of diversion of trophic substances in the portal blood rather than of a decrease in absolute liver flow. Recovery of liver weight after partial hepatectomy in portacavally transposed animals occurs within the same time as in control animals, and the time course and magnitude of regenerative hyperplasia, as assessed by liver DNA activity ratio, is unimpaired.

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Year:  1977        PMID： 861164      PMCID： PMC2041272     

Source DB:  PubMed          Journal:  Br J Exp Pathol        ISSN： 0007-1021


  14 in total

1.  The response of the rat liver to alterations in total portal blood flow.

Authors:  K Weinbren; S L Washington; C Y Smith
Journal:  Br J Exp Pathol       Date:  1975-04

2.  Liver regeneration following portacaval shunt.

Authors:  B FISHER; S H LEE; E R FISHER; E SAFFER
Journal:  Surgery       Date:  1962-07       Impact factor: 3.982

3.  The relation between hepatic flow and function in normal dogs and dogs with cirrhosis after portacaval shunt or transposition.

Authors:  F W HEER; D E SILVIUS; H A HARPER
Journal:  Surg Forum       Date:  1960

4.  The portal blood supply and regeneration of the rat liver.

Authors:  K WEINBREN
Journal:  Br J Exp Pathol       Date:  1955-12

5.  Portacaval transposition in the rat: a new technique and its effects on liver and body weight.

Authors:  C J Ryan; I S Benjamin; L H Blumgart
Journal:  Br J Surg       Date:  1974-03       Impact factor: 6.939

6.  The development of a proliferative response in liver parenchyma deprived of portal blood flow.

Authors:  K Weinbren; G A Stirling; S L Washington
Journal:  Br J Exp Pathol       Date:  1972-02

7.  Increased incorporation of 3H-thymidine into rat liver DNA after handling of liver lobes.

Authors:  K Weinbren; G M Arden; G A Stirling
Journal:  Br J Exp Pathol       Date:  1969-12

8.  The effects of cortisol and chlorazanil on the mitotic rate in mouse liver and skin.

Authors:  T A Hyde; J C Davis
Journal:  Eur J Cancer       Date:  1966-08       Impact factor: 9.162

9.  Effects of insulin, glucagon, and insuling/glucagon infusions on liver morphology and cell division after complete portacaval shunt in dogs.

Authors:  T E Starzl; K Watanabe; K A Porter; C W Putnam
Journal:  Lancet       Date:  1976-04-17       Impact factor: 79.321

10.  Portal hepatotrophic factors, diabetes mellitus and acute liver atrophy, hypertrophy and regeneration.

Authors:  T E Starzl; K A Porter; N Kashiwagi
Journal:  Surg Gynecol Obstet       Date:  1975-12
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  8 in total

1.  The effect of splanchnic viscera removal upon canine liver regeneration.

Authors:  T E Starzl; A Francavilla; K A Porter; J Benichou; A F Jones
Journal:  Surg Gynecol Obstet       Date:  1978-08

2.  Ultrastructural characteristics of hyperplastic alterations in the liver of congenital portacaval-shunt rats.

Authors:  F J Vonnahme; L Dubuisson; R Kubale; R Klempnauer; M Grün
Journal:  Br J Exp Pathol       Date:  1984-10

3.  Hepatic blood flow studies in the rat before and after portacaval transposition.

Authors:  C J Ryan; J Guest; S Ryan; A M Harper; L H Blumgart
Journal:  Br J Exp Pathol       Date:  1978-02

4.  Liver blood flow measurements in the portacavally transposed rat before and after partial hepatectomy.

Authors:  C J Ryan; J Guest; A M Harper; L H Blumgart
Journal:  Br J Exp Pathol       Date:  1978-04

5.  The effects of intravenously infused catecholamines on hepatic blood flow in conscious dogs with experimental obstructive jaundice.

Authors:  Y Kitagawa; Y Nimura; H Kanda; T Uematsu; S Kamiya; Y Machiki; T Watanabe
Journal:  Surg Today       Date:  1996       Impact factor: 2.549

6.  Changes in the nuclei of astrocytes following portacaval shunting and portacaval transposition in the rat.

Authors:  D Doyle; C J Ryan; I S Benjamin; L H Blumgart
Journal:  Br J Exp Pathol       Date:  1978-10

Review 7.  Hepatic nervous system and neurobiology of the liver.

Authors:  Kendal Jay Jensen; Gianfranco Alpini; Shannon Glaser
Journal:  Compr Physiol       Date:  2013-04       Impact factor: 9.090

8.  Activated charcoal haemoperfusion via an extracorporeal circuit in the unrestrained and unanaesthetized rat.

Authors:  C J Ryan; J M Courtney; C B Wood; R G Hood; L H Blumgart
Journal:  Br J Exp Pathol       Date:  1979-08
  8 in total

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