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Literature DB >> 8605099

Allelic imbalance in the region of the BRCA1 gene in ductal carcinoma in situ of the breast.

K E Munn¹, R A Walker, L Menasce, J M Varley.

Abstract

Thirty-four cases of ductal carcinoma in situ (DCIS) of the breast, with or without associated benign or invasive disease, were analysed for allelic imbalance (AI) in the region of the BRCA1 gene. AI on 17q12-23 in DCIS was demonstrated in 74% of cases, and in the majority of cases the region of AI included the BRCA1 gene. However, two cases showed AI distal to BRCA1, supporting the presence of a second tumour-suppressor gene on 17q.

Entities: Disease Gene

Mesh：

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Year: 1996 PMID： 8605099 PMCID： PMC2074329 DOI： 10.1038/bjc.1996.110

Source DB: PubMed Journal: Br J Cancer ISSN： 0007-0920 Impact factor: 7.640

23 in total

1. A simple sequence repeat polymorphism at the human growth hormone locus.

Authors: M H Polymeropoulos; D S Rath; H Xiao; C R Merril
Journal: Nucleic Acids Res Date: 1991-02-11 Impact factor: 16.971

2. Dinucleotide repeat polymorphisms at the D17S250 and D17S261 loci.

Authors: J L Weber; A E Kwitek; P E May; M R Wallace; F S Collins; D H Ledbetter
Journal: Nucleic Acids Res Date: 1990-08-11 Impact factor: 16.971

3. Somatic allelic deletion of nm23 in human cancer.

Authors: A Leone; O W McBride; A Weston; M G Wang; P Anglard; C S Cropp; J R Goepel; R Lidereau; R Callahan; W M Linehan
Journal: Cancer Res Date: 1991-05-01 Impact factor: 12.701

4. Detection of frequent allelic loss on proximal chromosome 17q in sporadic breast carcinoma using microsatellite length polymorphisms.

Authors: P A Futreal; P Söderkvist; J R Marks; J D Iglehart; C Cochran; J C Barrett; R W Wiseman
Journal: Cancer Res Date: 1992-05-01 Impact factor: 12.701

5. The human prohibitin gene located on chromosome 17q21 is mutated in sporadic breast cancer.

Authors: T Sato; H Saito; J Swensen; A Olifant; C Wood; D Danner; T Sakamoto; K Takita; F Kasumi; Y Miki
Journal: Cancer Res Date: 1992-03-15 Impact factor: 12.701

6. A comparison of the results of long-term follow-up for atypical intraductal hyperplasia and intraductal hyperplasia of the breast.

Authors: F A Tavassoli; H J Norris
Journal: Cancer Date: 1990-02-01 Impact factor: 6.860

7. Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up.

Authors: C W Elston; I O Ellis
Journal: Histopathology Date: 1991-11 Impact factor: 5.087

3. Genetic alterations on chromosome 16 and 17 are important features of ductal carcinoma in situ of the breast and are associated with histologic type.

Authors: C B Vos; N T ter Haar; C Rosenberg; J L Peterse; A M Cleton-Jansen; C J Cornelisse; M J van de Vijver
Journal: Br J Cancer Date: 1999-12 Impact factor: 7.640

4. Loss of heterozygosity at chromosome 9p in ductal carcinoma in situ and invasive carcinoma of the breast.

Authors: K L Marsh; J M Varley
Journal: Br J Cancer Date: 1998-05 Impact factor: 7.640

4 in total

Allelic imbalance in the region of the BRCA1 gene in ductal carcinoma in situ of the breast.

1. A simple sequence repeat polymorphism at the human growth hormone locus.

2. Dinucleotide repeat polymorphisms at the D17S250 and D17S261 loci.

3. Somatic allelic deletion of nm23 in human cancer.

4. Detection of frequent allelic loss on proximal chromosome 17q in sporadic breast carcinoma using microsatellite length polymorphisms.

5. The human prohibitin gene located on chromosome 17q21 is mutated in sporadic breast cancer.

6. A comparison of the results of long-term follow-up for atypical intraductal hyperplasia and intraductal hyperplasia of the breast.

7. Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up.

8. The HER2 (c-erbB-2) oncogene is frequently amplified in in situ carcinomas of the breast.

9. Intraductal carcinoma of the breast: follow-up after biopsy only.

10. Risk factors for breast cancer in women with proliferative breast disease.

1. Mutation of the TP53 gene and allelic imbalance at chromosome 17p13 in ductal carcinoma in situ.

2. Genetically abnormal clones in histologically normal breast tissue.

3. Genetic alterations on chromosome 16 and 17 are important features of ductal carcinoma in situ of the breast and are associated with histologic type.

4. Loss of heterozygosity at chromosome 9p in ductal carcinoma in situ and invasive carcinoma of the breast.