Literature DB >> 2015608

Somatic allelic deletion of nm23 in human cancer.

A Leone1, O W McBride, A Weston, M G Wang, P Anglard, C S Cropp, J R Goepel, R Lidereau, R Callahan, W M Linehan.   

Abstract

Tumor progression to the metastatic phenotype is accompanied in certain cell types by reduced expression of the nm23 gene. We have localized human nm23-H1 to chromosome 17 by somatic cell hybrid analysis. Regional localization in the CEPH database and in situ hybridization is reported. Somatic allelic deletion of nm23-H1 was observed in human breast, renal, colorectal, and lung carcinoma DNA samples, as compared to DNA from matched normal tissues. A homozygous deletion of nm23-H1 was observed in a lymph node metastasis of a colorectal carcinoma, indicating that nm23-H1 can be recessively inactivated. The data identify nm23-H1 as a novel, independent locus for allelic deletion in human cancer, a characteristic shared with previously described suppressor genes.

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Year:  1991        PMID： 2015608

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  36 in total

1.  Clinical significance of nm23 expression and chromosome 17 numerical aberrations in primary gastric cancer.

Authors:  Ryusuke Terada; Toru Yasutake; Shirou Nakamura; Takashi Hisamatsu; Terumitsu Sawai; Hiroyuki Yamaguchi; Tohru Nakagoe; Hiroyoshi Ayabe; Yutaka Tagawa
Journal:  Med Oncol       Date:  2002       Impact factor: 3.064

2.  Loss of heterozygosity of the nm23-H1 gene in human renal cell carcinomas.

Authors:  M H Bosnar; K Pavelić; R Hrasćan; Z Zeljko; I Krhen; Z Marekoyic; S Krizanac; J Pavelíc
Journal:  J Cancer Res Clin Oncol       Date:  1997       Impact factor: 4.553

3.  Closing in on a breast cancer gene on chromosome 17q.

Authors:  J M Hall; L Friedman; C Guenther; M K Lee; J L Weber; D M Black; M C King
Journal:  Am J Hum Genet       Date:  1992-06       Impact factor: 11.025

4.  Nm23-H1: genetic alterations and expression patterns in tumor metastasis.

Authors:  M T Hartsough; P S Steeg
Journal:  Am J Hum Genet       Date:  1998-07       Impact factor: 11.025

5.  Suppression of human melanoma metastasis following introduction of chromosome 6 is independent of NME1 (Nm23).

Authors:  M E Miele; A De La Rosa; J H Lee; D J Hicks; J U Dennis; P S Steeg; D R Welch
Journal:  Clin Exp Metastasis       Date:  1997-05       Impact factor: 5.150

6.  mRNA levels of nm23 in murine ascites hepatoma (H22) clones with different lymphatic metastatic potential.

Authors:  X P Jiang; Z Y Tang; K D Liu; X D Zhou; Z Y Lin; M Y Ling; X F Wu
Journal:  J Cancer Res Clin Oncol       Date:  1996       Impact factor: 4.553

7.  Deletions on the long arm of chromosome 17 in pilocytic astrocytoma.

Authors:  A von Deimling; D N Louis; A G Menon; K von Ammon; I Petersen; D Ellison; O D Wiestler; B R Seizinger
Journal:  Acta Neuropathol       Date:  1993       Impact factor: 17.088

8.  Isolation and characterization of the human genomic locus coding for the putative metastasis control gene nm23-H1.

Authors:  S Dooley; T Seib; M Engel; B Theisinger; H Janz; K Piontek; K D Zang; C Welter
Journal:  Hum Genet       Date:  1994-01       Impact factor: 4.132

9.  Linkage to markers for the chromosome region 17q12-q21 in 13 Dutch breast cancer kindreds.

Authors:  P Devilee; R S Cornelis; A Bootsma; A Bardoel; M van Vliet; I van Leeuwen; F J Cleton; A de Klein; D Lindhout; H F Vasen
Journal:  Am J Hum Genet       Date:  1993-04       Impact factor: 11.025

Review 10.  Nm23 and breast cancer metastasis.

Authors:  P S Steeg; A de la Rosa; U Flatow; N J MacDonald; M Benedict; A Leone
Journal:  Breast Cancer Res Treat       Date:  1993       Impact factor: 4.872
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