Literature DB >> 8578614

Nonlinear regression using spreadsheets.

W P Bowen1, J C Jerman.   

Abstract

Pharmacologists are often required to analyse nonlinear experimental effects by fitting the data to defined theoretical models. This may require a specialized computer program capable of performing nonlinear regression analysis, which can prove costly given the variety of pharmacological research. Here, Wayne Bowen and Jeff Jerman describe a generic method of performing nonlinear regression using spreadsheet applications, and demonstrate how this approach can be used to create automated systems of data analysis.

Mesh:

Year:  1995        PMID: 8578614     DOI: 10.1016/s0165-6147(00)89091-4

Source DB:  PubMed          Journal:  Trends Pharmacol Sci        ISSN: 0165-6147            Impact factor:   14.819


  29 in total

1.  [(3)H]-SB-269970--A selective antagonist radioligand for 5-HT(7) receptors.

Authors:  D R Thomas; P J Atkinson; M Ho; S M Bromidge; P J Lovell; A J Villani; J J Hagan; D N Middlemiss; G W Price
Journal:  Br J Pharmacol       Date:  2000-05       Impact factor: 8.739

2.  The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen.

Authors:  M D Wood; K L Murkitt; S Q Rice; T Testa; P K Punia; M Stammers; O Jenkins; N A Elshourbagy; U Shabon; S J Taylor; T L Gager; J Minton; W D Hirst; G W Price; M Pangalos
Journal:  Br J Pharmacol       Date:  2000-11       Impact factor: 8.739

3.  Characterization of SB-271046: a potent, selective and orally active 5-HT(6) receptor antagonist.

Authors:  C Routledge; S M Bromidge; S F Moss; G W Price; W Hirst; H Newman; G Riley; T Gager; T Stean; N Upton; S E Clarke; A M Brown; D N Middlemiss
Journal:  Br J Pharmacol       Date:  2000-08       Impact factor: 8.739

4.  SB-272183, a selective 5-HT(1A), 5-HT(1B) and 5-HT(1D) receptor antagonist in native tissue.

Authors:  J Watson; C Roberts; C Scott; I Kendall; L Collin; N C Day; M H Harries; E Soffin; C H Davies; A D Randall; T Heightman; L Gaster; P Wyman; C Parker; G W Price; D N Middlemiss
Journal:  Br J Pharmacol       Date:  2001-07       Impact factor: 8.739

5.  GABA(B2) is essential for g-protein coupling of the GABA(B) receptor heterodimer.

Authors:  M J Robbins; A R Calver; A K Filippov; W D Hirst; R B Russell; M D Wood; S Nasir; A Couve; D A Brown; S J Moss; M N Pangalos
Journal:  J Neurosci       Date:  2001-10-15       Impact factor: 6.167

6.  The C-terminal domains of the GABA(b) receptor subunits mediate intracellular trafficking but are not required for receptor signaling.

Authors:  A R Calver; M J Robbins; C Cosio; S Q Rice; A J Babbs; W D Hirst; I Boyfield; M D Wood; R B Russell; G W Price; A Couve; S J Moss; M N Pangalos
Journal:  J Neurosci       Date:  2001-02-15       Impact factor: 6.167

7.  Bgp, a secreted glycosaminoglycan-binding protein of Borrelia burgdorferi strain N40, displays nucleosidase activity and is not essential for infection of immunodeficient mice.

Authors:  Nikhat Parveen; Kenneth A Cornell; James L Bono; Christen Chamberland; Patricia Rosa; John M Leong
Journal:  Infect Immun       Date:  2006-05       Impact factor: 3.441

8.  Differential postmortem delay effect on agonist-mediated phospholipase Cbeta activity in human cortical crude and synaptosomal brain membranes.

Authors:  M Asier Garro; Maider López de Jesús; Iñigo Ruíz de Azúa; Luis F Callado; J Javier Meana; Joan Sallés
Journal:  Neurochem Res       Date:  2004-07       Impact factor: 3.996

9.  Monodisperse protein-based glycopolymers via a combined biosynthetic and chemical approach.

Authors:  Ying Wang; Kristi L Kiick
Journal:  J Am Chem Soc       Date:  2005-11-30       Impact factor: 15.419

10.  Comparison of the functional potencies of ropinirole and other dopamine receptor agonists at human D2(long), D3 and D4.4 receptors expressed in Chinese hamster ovary cells.

Authors:  M C Coldwell; I Boyfield; T Brown; J J Hagan; D N Middlemiss
Journal:  Br J Pharmacol       Date:  1999-08       Impact factor: 8.739

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