Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 GABA(B2) is essential for g-protein coupling of the GABA(B) receptor heterodimer.

Literature DB >> 11588177

GABA(B2) is essential for g-protein coupling of the GABA(B) receptor heterodimer.

M J Robbins¹, A R Calver, A K Filippov, W D Hirst, R B Russell, M D Wood, S Nasir, A Couve, D A Brown, S J Moss, M N Pangalos.

Abstract

GABA(B) receptors are unique among G-protein-coupled receptors (GPCRs) in their requirement for heterodimerization between two homologous subunits, GABA(B1) and GABA(B2), for functional expression. Whereas GABA(B1) is capable of binding receptor agonists and antagonists, the role of each GABA(B) subunit in receptor signaling is unknown. Here we identified amino acid residues within the second intracellular domain of GABA(B2) that are critical for the coupling of GABA(B) receptor heterodimers to their downstream effector systems. Our results provide strong evidence for a functional role of the GABA(B2) subunit in G-protein coupling of the GABA(B) receptor heterodimer. In addition, they provide evidence for a novel "sequential" GPCR signaling mechanism in which ligand binding to one heterodimer subunit can induce signal transduction through the second partner of a heteromeric complex.

Entities: Chemical

Mesh：

Substances：

Year: 2001 PMID： 11588177 PMCID： PMC6763845

Source DB: PubMed Journal: J Neurosci ISSN： 0270-6474 Impact factor: 6.167

36 in total

1. The N-terminal domain of gamma-aminobutyric Acid(B) receptors is sufficient to specify agonist and antagonist binding.

Authors: B Malitschek; C Schweizer; M Keir; J Heid; W Froestl; J Mosbacher; R Kuhn; J Henley; C Joly; J P Pin; K Kaupmann; B Bettler
Journal: Mol Pharmacol Date: 1999-08 Impact factor: 4.436

2. The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen.

Authors: M D Wood; K L Murkitt; S Q Rice; T Testa; P K Punia; M Stammers; O Jenkins; N A Elshourbagy; U Shabon; S J Taylor; T L Gager; J Minton; W D Hirst; G W Price; M Pangalos
Journal: Br J Pharmacol Date: 2000-11 Impact factor: 8.739

3. Heterodimerization of mu and delta opioid receptors: A role in opiate synergy.

Authors: I Gomes; B A Jordan; A Gupta; N Trapaidze; V Nagy; L A Devi
Journal: J Neurosci Date: 2000-11-15 Impact factor: 6.167

4. A trafficking checkpoint controls GABA(B) receptor heterodimerization.

Authors: M Margeta-Mitrovic; Y N Jan; L Y Jan
Journal: Neuron Date: 2000-07 Impact factor: 17.173

5. Intracellular retention of recombinant GABAB receptors.

Authors: A Couve; A K Filippov; C N Connolly; B Bettler; D A Brown; S J Moss
Journal: J Biol Chem Date: 1998-10-09 Impact factor: 5.157

6. ALSCRIPT: a tool to format multiple sequence alignments.

Authors: G J Barton
Journal: Protein Eng Date: 1993-01

7. Nonlinear regression using spreadsheets.

Authors: W P Bowen; J C Jerman
Journal: Trends Pharmacol Sci Date: 1995-12 Impact factor: 14.819

8. Identification of a GABAB receptor subunit, gb2, required for functional GABAB receptor activity.

Authors: G Y Ng; J Clark; N Coulombe; N Ethier; T E Hebert; R Sullivan; S Kargman; A Chateauneuf; N Tsukamoto; T McDonald; P Whiting; E Mezey; M P Johnson; Q Liu; L F Kolakowski; J F Evans; T I Bonner; G P O'Neill
Journal: J Biol Chem Date: 1999-03-19 Impact factor: 5.157

9. Ca(2+) requirement for high-affinity gamma-aminobutyric acid (GABA) binding at GABA(B) receptors: involvement of serine 269 of the GABA(B)R1 subunit.

Authors: T Galvez; S Urwyler; L Prézeau; J Mosbacher; C Joly; B Malitschek; J Heid; I Brabet; W Froestl; B Bettler; K Kaupmann; J P Pin
Journal: Mol Pharmacol Date: 2000-03 Impact factor: 4.436

10. The second intracellular loop of metabotropic glutamate receptor 1 cooperates with the other intracellular domains to control coupling to G-proteins.

Authors: J Gomeza; C Joly; R Kuhn; T Knöpfel; J Bockaert; J P Pin
Journal: J Biol Chem Date: 1996-01-26 Impact factor: 5.157

63 in total

1. GABA(B) receptor GTP-binding is decreased in the prefrontal cortex but not the hippocampus of aged rats.

Authors: Joseph A McQuail; Cristina Bañuelos; Candi L LaSarge; Michelle M Nicolle; Jennifer L Bizon
Journal: Neurobiol Aging Date: 2011-12-14 Impact factor: 4.673

2. The heptahelical domain of GABA(B2) is activated directly by CGP7930, a positive allosteric modulator of the GABA(B) receptor.

Authors: Virginie Binet; Carole Brajon; Laurent Le Corre; Francine Acher; Jean-Philippe Pin; Laurent Prézeau
Journal: J Biol Chem Date: 2004-05-04 Impact factor: 5.157

Review 3. Orphan G protein-coupled receptors (GPCRs): biological functions and potential drug targets.

Authors: Xiao-long Tang; Ying Wang; Da-li Li; Jian Luo; Ming-yao Liu
Journal: Acta Pharmacol Sin Date: 2012-02-27 Impact factor: 6.150

4. Probing novel GPCR interactions using a combination of FRET and TIRF.

Authors: Stephanie B Boyer; Paul A Slesinger
Journal: Commun Integr Biol Date: 2010-07

5. Prolonged activation of NMDA receptors promotes dephosphorylation and alters postendocytic sorting of GABAB receptors.

Authors: Miho Terunuma; Karina J Vargas; Megan E Wilkins; Omar A Ramírez; Matías Jaureguiberry-Bravo; Menelas N Pangalos; Trevor G Smart; Stephen J Moss; Andrés Couve
Journal: Proc Natl Acad Sci U S A Date: 2010-07-19 Impact factor: 11.205

6. Spatial Clustering of de Novo Missense Mutations Identifies Candidate Neurodevelopmental Disorder-Associated Genes.

Authors: Stefan H Lelieveld; Laurens Wiel; Hanka Venselaar; Rolph Pfundt; Gerrit Vriend; Joris A Veltman; Han G Brunner; Lisenka E L M Vissers; Christian Gilissen
Journal: Am J Hum Genet Date: 2017-08-31 Impact factor: 11.025

7. Studies of GABA(B) receptors labelled with [(3)H]-CGP62349 in hippocampus resected from patients with temporal lobe epilepsy.

Authors: A P Princivalle; J S Duncan; M Thom; N G Bowery
Journal: Br J Pharmacol Date: 2002-08 Impact factor: 8.739