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Literature DB >> 16622242

Bgp, a secreted glycosaminoglycan-binding protein of Borrelia burgdorferi strain N40, displays nucleosidase activity and is not essential for infection of immunodeficient mice.

Nikhat Parveen¹, Kenneth A Cornell, James L Bono, Christen Chamberland, Patricia Rosa, John M Leong.

Abstract

Bgp, one of the surface-localized glycosaminoglycan-binding proteins of the Lyme disease spirochete, Borrelia burgdorferi, exhibited nucleosidase activity. Infection of SCID mice with B. burgdorferi strain N40 mutants harboring a targeted insertion in bgp and apparently retaining all endogenous plasmids revealed that Bgp is not essential for colonization of immunocompromised mice.

Entities: Disease Species

Mesh：

Substances：

Year: 2006 PMID： 16622242 PMCID： PMC1459710 DOI： 10.1128/IAI.74.5.3016-3020.2006

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

56 in total

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5. Quorum-sensing Escherichia coli regulator A: a regulator of the LysR family involved in the regulation of the locus of enterocyte effacement pathogenicity island in enterohemorrhagic E. coli.

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Journal: Infect Immun Date: 2002-06 Impact factor: 3.441

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8. Adaptation of the Lyme disease spirochaete to the mammalian host environment results in enhanced glycosaminoglycan and host cell binding.

Authors: Nikhat Parveen; Melissa Caimano; Justin D Radolf; John M Leong
Journal: Mol Microbiol Date: 2003-03 Impact factor: 3.501

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Journal: Infect Immun Date: 1995-09 Impact factor: 3.441

38 in total

1. Molecular determinants of substrate specificity in plant 5'-methylthioadenosine nucleosidases.

Authors: Karen K W Siu; Jeffrey E Lee; Janice R Sufrin; Barbara A Moffatt; Martin McMillan; Kenneth A Cornell; Chelsea Isom; P Lynne Howell
Journal: J Mol Biol Date: 2008-02-08 Impact factor: 5.469

2. Borrelia burgdorferi lacking DbpBA exhibits an early survival defect during experimental infection.

Authors: Eric H Weening; Nikhat Parveen; Jerome P Trzeciakowski; John M Leong; Magnus Höök; Jonathan T Skare
Journal: Infect Immun Date: 2008-09-22 Impact factor: 3.441

3. The Borrelia burgdorferi integrin ligand P66 affects gene expression by human cells in culture.

Authors: Michelle E LaFrance; Jessica V Pierce; Syliani Antonara; Jenifer Coburn
Journal: Infect Immun Date: 2011-05-16 Impact factor: 3.441

4. Genetic Transformation and Complementation.

Authors: D Scott Samuels; Dan Drecktrah; Laura S Hall
Journal: Methods Mol Biol Date: 2018

5. Detection of established virulence genes and plasmids to differentiate Borrelia burgdorferi strains.

Authors: Kamfai Chan; Sherwood Casjens; Nikhat Parveen
Journal: Infect Immun Date: 2012-01-30 Impact factor: 3.441

6. Vascular binding of a pathogen under shear force through mechanistically distinct sequential interactions with host macromolecules.

Authors: Tara J Moriarty; Meiqing Shi; Yi-Pin Lin; Rhodaba Ebady; Hong Zhou; Tanya Odisho; Pierre-Olivier Hardy; Aydan Salman-Dilgimen; Jing Wu; Eric H Weening; Jon T Skare; Paul Kubes; John Leong; George Chaconas
Journal: Mol Microbiol Date: 2012-10-24 Impact factor: 3.501