Literature DB >> 8576062

Cloning and heterologous expression of the entire set of structural genes for nikkomycin synthesis from Streptomyces tendae Tü901 in Streptomyces lividans.

C Bormann1, V Möhrle, C Bruntner.   

Abstract

A genomic library from Streptomyces tendae raised in shuttle cosmid vector pKC505 was screened with a previously isolated 8-kb DNA fragment containing the orfP1 gene, which is involved in nikkomycin biosynthesis. The entire set of structural genes for nikkomycin synthesis was heterologously expressed in S. lividans TK23 by introducing recombinant cosmids p24/32 and p9/43-2, carrying inserts of about 31 and 27 kb, respectively, overlapping by 15 kb. S. lividans transformants synthesized nikkomycins X, Z, I, and J, which were identified by high-pressure liquid chromatography analyses of culture filtrates.

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Year:  1996        PMID： 8576062      PMCID： PMC177789          DOI： 10.1128/jb.178.4.1216-1218.1996

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  8 in total

Review 1.  Organization and expression of genes involved in the biosynthesis of antibiotics and other secondary metabolites.

Authors:  M F Martín; P Liras
Journal:  Annu Rev Microbiol       Date:  1989       Impact factor: 15.500

2.  Isolation of Streptomyces tendae mutants with an altered nikkomycin spectrum.

Authors:  C Bormann; S Mattern; H Schrempf; H P Fiedler; H Zähner
Journal:  J Antibiot (Tokyo)       Date:  1989-06       Impact factor: 2.649

3.  Identification of cellular proteins involved in nikkomycin production in Streptomyces tendae Tü901.

Authors:  V Möhrle; U Roos; C Bormann
Journal:  Mol Microbiol       Date:  1995-02       Impact factor: 3.501

4.  Screening for new microbial products by high-performance liquid chromatography using a photodiode array detector.

Authors:  H P Fiedler
Journal:  J Chromatogr       Date:  1984-12-21

5.  Stoffwechselprodukte von mikroorganismen. 154. Mitteilung. Nikkomycin, ein neuer hemmstoff der chitinsynthese bei pilzen.

Authors:  U Dähn; H Hagenmaier; H Höhne; W A König; G Wolf; H Zähner
Journal:  Arch Microbiol       Date:  1976-03-19       Impact factor: 2.552

6.  A new shuttle cosmid vector, pKC505, for streptomycetes: its use in the cloning of three different spiramycin-resistance genes from a Streptomyces ambofaciens library.

Authors:  M A Richardson; S Kuhstoss; P Solenberg; N A Schaus; R N Rao
Journal:  Gene       Date:  1987       Impact factor: 3.688

7.  Metabolic products of microorganisms. 228. New nikkomycins produced by mutants of Streptomyces tendae.

Authors:  C Bormann; W Huhn; H Zähner; R Rathmann; H Hahn; W A König
Journal:  J Antibiot (Tokyo)       Date:  1985-01       Impact factor: 2.649

8.  Metabolic products of microorganisms. 181. Chitin synthase from fungi, a test model for substances with insecticidal properties.

Authors:  G U Brillinger
Journal:  Arch Microbiol       Date:  1979-04       Impact factor: 2.552
  8 in total
  7 in total

Review 1.  Nature's combinatorial biosynthesis and recently engineered production of nucleoside antibiotics in Streptomyces.

Authors:  Shawn Chen; William A Kinney; Steven Van Lanen
Journal:  World J Microbiol Biotechnol       Date:  2017-03-04       Impact factor: 3.312

Review 2.  Streptomyces and Saccharopolyspora hosts for heterologous expression of secondary metabolite gene clusters.

Authors:  Richard H Baltz
Journal:  J Ind Microbiol Biotechnol       Date:  2010-05-14       Impact factor: 3.346

3.  In vitro antifungal activity of nikkomycin Z in combination with fluconazole or itraconazole.

Authors:  R K Li; M G Rinaldi
Journal:  Antimicrob Agents Chemother       Date:  1999-06       Impact factor: 5.191

Review 4.  Natural and engineered biosynthesis of nucleoside antibiotics in Actinomycetes.

Authors:  Wenqing Chen; Jianzhao Qi; Pan Wu; Dan Wan; Jin Liu; Xuan Feng; Zixin Deng
Journal:  J Ind Microbiol Biotechnol       Date:  2015-07-08       Impact factor: 3.346

5.  Streptomyces lividans blasticidin S deaminase and its application in engineering a blasticidin S-producing strain for ease of genetic manipulation.

Authors:  Li Li; Jun Wu; Zixin Deng; T Mark Zabriskie; Xinyi He
Journal:  Appl Environ Microbiol       Date:  2013-02-01       Impact factor: 4.792

Review 6.  Identification and characterization of enzymes involved in the biosynthesis of pyrimidine nucleoside antibiotics.

Authors:  M McErlean; X Liu; Z Cui; B Gust; S G Van Lanen
Journal:  Nat Prod Rep       Date:  2021-07-21       Impact factor: 15.111

7.  Development of an intergeneric conjugal transfer system for xinaomycins-producing Streptomyces noursei Xinao-4.

Authors:  Feng-Hui Sun; Di Luo; Dan Shu; Juan Zhong; Hong Tan
Journal:  Int J Mol Sci       Date:  2014-07-09       Impact factor: 5.923
  7 in total

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