Literature DB >> 8567959

Regulation of transforming growth factor-beta 1 expression by the hepatitis B virus (HBV) X transactivator. Role in HBV pathogenesis.

Y D Yoo1, H Ueda, K Park, K C Flanders, Y I Lee, G Jay, S J Kim.   

Abstract

TGF-beta 1 has been implicated in the pathogenesis of liver disease. The high frequency of detection of the hepatitis B virus X (HBx) antigen in liver cells from patients with chronic hepatitis, cirrhosis, and liver cancer suggested that expression of HBx and TGF-beta 1 may be associated. To test this possibility, we examined the expression of TGF-beta 1 in the liver of transgenic mice expressing the HBx gene. We show that the patterns of expression of TGF-beta 1 and Hbx protein are similar in these mice and that HBx activates transcription of the TGF-beta 1 gene in transfected hepatoma cells. The cis-acting element within the TGF-beta 1 gene that is responsive to regulation by Hbx is the binding site for the Egr family of transcription factors. We further show that the Egr-1 protein associates with the HBx protein, allowing HBx to participate in the transcriptional regulation of immediate-early genes. Our results suggest that expression of Hbx might induce expression of TGF-beta 1 in the early stages of infection and raise the possibility that TGF-beta 1 may play a role in hepatitis B virus pathogenesis.

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Year:  1996        PMID： 8567959      PMCID： PMC507029          DOI： 10.1172/JCI118427

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  66 in total

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3.  Cloning of tetradecanoyl phorbol ester-induced 'primary response' sequences and their expression in density-arrested Swiss 3T3 cells and a TPA non-proliferative variant.

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Journal:  Oncogene       Date:  1987       Impact factor: 9.867

4.  Transforming growth factor beta mRNA increases during liver regeneration: a possible paracrine mechanism of growth regulation.

Authors:  L Braun; J E Mead; M Panzica; R Mikumo; G I Bell; N Fausto
Journal:  Proc Natl Acad Sci U S A       Date:  1988-03       Impact factor: 11.205

5.  Two mouse genes encoding potential transcription factors with identical DNA-binding domains are activated by growth factors in cultured cells.

Authors:  P Lemaire; O Revelant; R Bravo; P Charnay
Journal:  Proc Natl Acad Sci U S A       Date:  1988-07       Impact factor: 11.205

6.  Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB.

Authors:  K K Yamamoto; G A Gonzalez; W H Biggs; M R Montminy
Journal:  Nature       Date:  1988-08-11       Impact factor: 49.962

7.  The woodchuck hepatitis virus X gene is important for establishment of virus infection in woodchucks.

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Journal:  J Virol       Date:  1993-03       Impact factor: 5.103

8.  Repression of the insulin-like growth factor II gene by the Wilms tumor suppressor WT1.

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Journal:  Science       Date:  1992-07-31       Impact factor: 47.728

9.  A gene activated in mouse 3T3 cells by serum growth factors encodes a protein with "zinc finger" sequences.

Authors:  B A Christy; L F Lau; D Nathans
Journal:  Proc Natl Acad Sci U S A       Date:  1988-11       Impact factor: 11.205

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Authors:  A Panduro; F Shalaby; L Biempica; D A Shafritz
Journal:  Hepatology       Date:  1988 Mar-Apr       Impact factor: 17.425
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  37 in total

Review 1.  Molecular pathways in virus-induced cytokine production.

Authors:  T H Mogensen; S R Paludan
Journal:  Microbiol Mol Biol Rev       Date:  2001-03       Impact factor: 11.056

Review 2.  Pre-S2 Mutant-Induced Mammalian Target of Rapamycin Signal Pathways as Potential Therapeutic Targets for Hepatitis B Virus-Associated Hepatocellular Carcinoma.

Authors:  Chiao-Fang Teng; Han-Chieh Wu; Woei-Cherng Shyu; Long-Bin Jeng; Ih-Jen Su
Journal:  Cell Transplant       Date:  2017-02-14       Impact factor: 4.064

3.  The hepatitis B virus X protein promotes tumor cell invasion by inducing membrane-type matrix metalloproteinase-1 and cyclooxygenase-2 expression.

Authors:  Enrique Lara-Pezzi; Maria Victoria Gómez-Gaviro; Beatriz G Gálvez; Emilia Mira; Miguel A Iñiguez; Manuel Fresno; Carlos Martínez-A; Alicia G Arroyo; Manuel López-Cabrera
Journal:  J Clin Invest       Date:  2002-12       Impact factor: 14.808

4.  c-ETS1 facilitates G1/S-phase transition by up-regulating cyclin E and CDK2 genes and cooperates with hepatitis B virus X protein for their deregulation.

Authors:  Anup Kumar Singh; Manickavinayaham Swarnalatha; Vijay Kumar
Journal:  J Biol Chem       Date:  2011-04-22       Impact factor: 5.157

Review 5.  Potential mechanisms of hepatitis B virus induced liver injury.

Authors:  Mohd Suhail; Hany Abdel-Hafiz; Ashraf Ali; Kaneez Fatima; Ghazi A Damanhouri; Esam Azhar; Adeel Ga Chaudhary; Ishtiaq Qadri
Journal:  World J Gastroenterol       Date:  2014-09-21       Impact factor: 5.742

6.  The hepatitis B virus encoded oncoprotein pX amplifies TGF-beta family signaling through direct interaction with Smad4: potential mechanism of hepatitis B virus-induced liver fibrosis.

Authors:  D K Lee; S H Park; Y Yi; S G Choi; C Lee; W T Parks; H Cho; M P de Caestecker; Y Shaul; A B Roberts; S J Kim
Journal:  Genes Dev       Date:  2001-02-15       Impact factor: 11.361

7.  The hepatitis B virus-associated tumor microenvironment in hepatocellular carcinoma.

Authors:  Pengyuan Yang; Geoffrey J Markowitz; Xiao-Fan Wang
Journal:  Natl Sci Rev       Date:  2014-07-14       Impact factor: 17.275

8.  Mitochondrially associated hepatitis B virus X protein constitutively activates transcription factors STAT-3 and NF-kappa B via oxidative stress.

Authors:  G Waris; K W Huh; A Siddiqui
Journal:  Mol Cell Biol       Date:  2001-11       Impact factor: 4.272

9.  The hepatitis B virus X protein activates nuclear factor of activated T cells (NF-AT) by a cyclosporin A-sensitive pathway.

Authors:  E Lara-Pezzi; A L Armesilla; P L Majano; J M Redondo; M López-Cabrera
Journal:  EMBO J       Date:  1998-12-01       Impact factor: 11.598

10.  Transforming growth factor beta/Smad3 signaling regulates IRF-7 function and transcriptional activation of the beta interferon promoter.

Authors:  Jing Qing; Cheng Liu; Lisa Choy; Rui-Yun Wu; Joseph S Pagano; Rik Derynck
Journal:  Mol Cell Biol       Date:  2004-02       Impact factor: 4.272
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