Literature DB >> 2900470

Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB.

K K Yamamoto1, G A Gonzalez, W H Biggs, M R Montminy.   

Abstract

A nuclear protein, CREB, has been isolated from rat brain and shown to stimulate transcription of the cyclic AMP-responsive gene somatostatin as a dimer. Biochemical analysis suggests that dimerization and transcriptional efficacy of CREB protein in vitro are regulated by phosphorylation. These findings demonstrate that cellular signals can modulate gene expression by regulating the covalent modification of pre-existing nuclear factors.

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Year:  1988        PMID： 2900470     DOI： 10.1038/334494a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  352 in total

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Authors:  A A McBride; J B Bolen; P M Howley
Journal:  J Virol       Date:  1989-12       Impact factor: 5.103

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Journal:  J Biol Chem       Date:  2012-10-04       Impact factor: 5.157
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