Literature DB >> 8552590

Identification, sequence, and expression of caveolin-2 defines a caveolin gene family.

P E Scherer1, T Okamoto, M Chun, I Nishimoto, H F Lodish, M P Lisanti.   

Abstract

Caveolin, a 21- to 24-kDa integral membrane protein, is a principal component of caveolae membranes. Caveolin interacts directly with heterotrimeric guanine nucleotide binding proteins (G proteins) and can functionally regulate their activity. Here, an approximately 20-kDa caveolin-related protein, caveolin-2, was identified through microsequencing of adipocyte-derived caveolin-enriched membranes; caveolin was retermed caveolin-1. Caveolins 1 and 2 are similar in most respects. mRNAs for both caveolin-1 and caveolin-2 are most abundantly expressed in white adipose tissue and are induced during adipocyte differentiation. Caveolin-2 colocalizes with caveolin-1, indicating that caveolin-2 also localizes to caveolae. However, caveolin-1 and caveolin-2 differ in their functional interactions with heterotrimeric G proteins, possibly explaining why caveolin-1 and -2 are coexpressed within a single cell.

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Year:  1996        PMID： 8552590      PMCID： PMC40192          DOI： 10.1073/pnas.93.1.131

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  28 in total

1.  The sequence of human caveolin reveals identity with VIP21, a component of transport vesicles.

Authors:  J R Glenney
Journal:  FEBS Lett       Date:  1992-12-07       Impact factor: 4.124

2.  Caveolin isoforms differ in their N-terminal protein sequence and subcellular distribution. Identification and epitope mapping of an isoform-specific monoclonal antibody probe.

Authors:  P E Scherer; Z Tang; M Chun; M Sargiacomo; H F Lodish; M P Lisanti
Journal:  J Biol Chem       Date:  1995-07-07       Impact factor: 5.157

3.  Oligomeric structure of caveolin: implications for caveolae membrane organization.

Authors:  M Sargiacomo; P E Scherer; Z Tang; E Kübler; K S Song; M C Sanders; M P Lisanti
Journal:  Proc Natl Acad Sci U S A       Date:  1995-09-26       Impact factor: 11.205

4.  A simple structure encodes G protein-activating function of the IGF-II/mannose 6-phosphate receptor.

Authors:  T Okamoto; T Katada; Y Murayama; M Ui; E Ogata; I Nishimoto
Journal:  Cell       Date:  1990-08-24       Impact factor: 41.582

5.  Isolation of two proteins with high affinity for guanine nucleotides from membranes of bovine brain.

Authors:  P C Sternweis; J D Robishaw
Journal:  J Biol Chem       Date:  1984-11-25       Impact factor: 5.157

Review 6.  Lipid modifications of trimeric G proteins.

Authors:  P B Wedegaertner; P T Wilson; H R Bourne
Journal:  J Biol Chem       Date:  1995-01-13       Impact factor: 5.157

7.  Morphological changes of the 3T3-L1 fibroblast plasma membrane upon differentiation to the adipocyte form.

Authors:  J Y Fan; J L Carpentier; E van Obberghen; C Grunfeld; P Gorden; L Orci
Journal:  J Cell Sci       Date:  1983-05       Impact factor: 5.285

8.  Characterization of caveolin-rich membrane domains isolated from an endothelial-rich source: implications for human disease.

Authors:  M P Lisanti; P E Scherer; J Vidugiriene; Z Tang; A Hermanowski-Vosatka; Y H Tu; R F Cook; M Sargiacomo
Journal:  J Cell Biol       Date:  1994-07       Impact factor: 10.539

9.  Caveolin moves from caveolae to the Golgi apparatus in response to cholesterol oxidation.

Authors:  E J Smart; Y S Ying; P A Conrad; R G Anderson
Journal:  J Cell Biol       Date:  1994-12       Impact factor: 10.539

10.  VIP21, a 21-kD membrane protein is an integral component of trans-Golgi-network-derived transport vesicles.

Authors:  T V Kurzchalia; P Dupree; R G Parton; R Kellner; H Virta; M Lehnert; K Simons
Journal:  J Cell Biol       Date:  1992-09       Impact factor: 10.539
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  151 in total

Review 1.  Caveolins, liquid-ordered domains, and signal transduction.

Authors:  E J Smart; G A Graf; M A McNiven; W C Sessa; J A Engelman; P E Scherer; T Okamoto; M P Lisanti
Journal:  Mol Cell Biol       Date:  1999-11       Impact factor: 4.272

2.  Compartmentalized signaling by GPI-anchored ephrin-A5 requires the Fyn tyrosine kinase to regulate cellular adhesion.

Authors:  A Davy; N W Gale; E W Murray; R A Klinghoffer; P Soriano; C Feuerstein; S M Robbins
Journal:  Genes Dev       Date:  1999-12-01       Impact factor: 11.361

3.  Identification of filamin as a novel ligand for caveolin-1: evidence for the organization of caveolin-1-associated membrane domains by the actin cytoskeleton.

Authors:  M Stahlhut; B van Deurs
Journal:  Mol Biol Cell       Date:  2000-01       Impact factor: 4.138

Review 4.  Caveolae: an alternative membrane transport compartment.

Authors:  M Gumbleton; A G Abulrob; L Campbell
Journal:  Pharm Res       Date:  2000-09       Impact factor: 4.200

Review 5.  Caveolin-deficient mice: insights into caveolar function human disease.

Authors:  B Razani; M P Lisanti
Journal:  J Clin Invest       Date:  2001-12       Impact factor: 14.808

6.  Expression of caveolin by bovine lymphocytes and antigen-presenting cells.

Authors:  James Harris; Dirk Werling; Michael Koss; Paul Monaghan; Geraldine Taylor; Chris J Howard
Journal:  Immunology       Date:  2002-02       Impact factor: 7.397

7.  Hypoxia induces cardiac fibroblast proliferation and phenotypic switch: a role for caveolae and caveolin-1/PTEN mediated pathway.

Authors:  Yao Gao; Ming Chu; Jian Hong; Jingping Shang; Di Xu
Journal:  J Thorac Dis       Date:  2014-10       Impact factor: 2.895

8.  Elevated inflammatory response in caveolin-1-deficient mice with Pseudomonas aeruginosa infection is mediated by STAT3 protein and nuclear factor kappaB (NF-kappaB).

Authors:  Kefei Yuan; Canhua Huang; John Fox; Madeleine Gaid; Andrew Weaver; Guoping Li; Brij B Singh; Hongwei Gao; Min Wu
Journal:  J Biol Chem       Date:  2011-04-22       Impact factor: 5.157

Review 9.  The evolving role of lipid rafts and caveolae in G protein-coupled receptor signaling: implications for molecular pharmacology.

Authors:  Rennolds S Ostrom; Paul A Insel
Journal:  Br J Pharmacol       Date:  2004-08-02       Impact factor: 8.739

10.  Modulation of myoblast fusion by caveolin-3 in dystrophic skeletal muscle cells: implications for Duchenne muscular dystrophy and limb-girdle muscular dystrophy-1C.

Authors:  Daniela Volonte; Aaron J Peoples; Ferruccio Galbiati
Journal:  Mol Biol Cell       Date:  2003-08-07       Impact factor: 4.138
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