Literature DB >> 7822269

Lipid modifications of trimeric G proteins.

P B Wedegaertner1, P T Wilson, H R Bourne.   

Abstract

G protein alpha subunits and beta gamma dimers are covalently modified by lipids. The emerging picture is one in which attached lipids provide more than just a nonspecific "glue" for sticking G proteins to membranes. We are only beginning to understand how different lipid modifications of different G protein subunits affect specific protein-protein interactions and localization to specific cellular sites. In addition, regulation of these modifications, particularly palmitoylation, can provide new ways to regulate signals transmitted by G proteins.

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Year:  1995        PMID： 7822269     DOI： 10.1074/jbc.270.2.503

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  120 in total

1.  A method for S- and O-palmitoylation of peptides: synthesis of pulmonary surfactant protein-C models.

Authors:  E Yousefi-Salakdeh; J Johansson; R Strömberg
Journal:  Biochem J       Date:  1999-11-01       Impact factor: 3.857

2.  Functional roles for fatty acylated amino-terminal domains in subcellular localization.

Authors:  J B McCabe; L G Berthiaume
Journal:  Mol Biol Cell       Date:  1999-11       Impact factor: 4.138

3.  Selective inactivation of guanine-nucleotide-binding regulatory protein (G-protein) alpha and betagamma subunits by urea.

Authors:  W K Lim; R R Neubig
Journal:  Biochem J       Date:  2001-03-01       Impact factor: 3.857

4.  Oxidative stress inhibits caveolin-1 palmitoylation and trafficking in endothelial cells.

Authors:  Marie-Odile Parat; Rafal Z Stachowicz; Paul L Fox
Journal:  Biochem J       Date:  2002-02-01       Impact factor: 3.857

5.  Galpha i3 binding to calnuc on Golgi membranes in living cells monitored by fluorescence resonance energy transfer of green fluorescent protein fusion proteins.

Authors:  T S Weiss; C E Chamberlain; T Takeda; P Lin; K M Hahn; M G Farquhar
Journal:  Proc Natl Acad Sci U S A       Date:  2001-12-18       Impact factor: 11.205

6.  A quantitative characterization of the yeast heterotrimeric G protein cycle.

Authors:  Tau-Mu Yi; Hiroaki Kitano; Melvin I Simon
Journal:  Proc Natl Acad Sci U S A       Date:  2003-09-05       Impact factor: 11.205

7.  Membrane trafficking of heterotrimeric G proteins via the endoplasmic reticulum and Golgi.

Authors:  David Michaelson; Ian Ahearn; Martin Bergo; Stephen Young; Mark Philips
Journal:  Mol Biol Cell       Date:  2002-09       Impact factor: 4.138

8.  Targeting of nitric oxide synthase to endothelial cell caveolae via palmitoylation: implications for nitric oxide signaling.

Authors:  G García-Cardeña; P Oh; J Liu; J E Schnitzer; W C Sessa
Journal:  Proc Natl Acad Sci U S A       Date:  1996-06-25       Impact factor: 11.205

9.  Role of lipid polymorphism in G protein-membrane interactions: nonlamellar-prone phospholipids and peripheral protein binding to membranes.

Authors:  P V Escribá; A Ozaita; C Ribas; A Miralles; E Fodor; T Farkas; J A García-Sevilla
Journal:  Proc Natl Acad Sci U S A       Date:  1997-10-14       Impact factor: 11.205

Review 10.  G-protein signaling: back to the future.

Authors:  C R McCudden; M D Hains; R J Kimple; D P Siderovski; F S Willard
Journal:  Cell Mol Life Sci       Date:  2005-03       Impact factor: 9.261
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