Literature DB >> 8550430

Serine protease EpiP from Staphylococcus epidermidis catalyzes the processing of the epidermin precursor peptide.

S Geissler1, F Götz, T Kupke.   

Abstract

The function of serine protease EpiP in epidermin biosynthesis was investigated. Epidermin is synthesized as a 52-amino-acid precursor peptide, EpiA, which is posttranslationally modified and processed to the mature 22-amino-acid peptide antibiotic. epiP was expressed in Staphylococcus carnosus with xylose-regulated expression vector pCX15. The cleavage of the unmodified EpiA precursor peptide to leader peptide and proepidermin by EpiP-containing culture filtrates of S. carnosus (pCX15epiP) was followed by reversed-phase chromatography and subsequent electrospray mass spectrometry.

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Year:  1996        PMID： 8550430      PMCID： PMC177651          DOI： 10.1128/jb.178.1.284-288.1996

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  41 in total

1.  Genetic analysis of epidermin biosynthetic genes and epidermin-negative mutants of Staphylococcus epidermidis.

Authors:  J Augustin; R Rosenstein; B Wieland; U Schneider; N Schnell; G Engelke; K D Entian; F Götz
Journal:  Eur J Biochem       Date:  1992-03-15

2.  Purification and characterization of EpiA, the peptide substrate for post-translational modifications involved in epidermin biosynthesis.

Authors:  T Kupke; S Stevanovic; B Ottenwälder; J W Metzger; G Jung; F Götz
Journal:  FEMS Microbiol Lett       Date:  1993-08-15       Impact factor: 2.742

3.  Cloning of the gene encoding Streptococcin A-FF22, a novel lantibiotic produced by Streptococcus pyogenes, and determination of its nucleotide sequence.

Authors:  W L Hynes; J J Ferretti; J R Tagg
Journal:  Appl Environ Microbiol       Date:  1993-06       Impact factor: 4.792

4.  Characterization of an extracellular metalloprotease with elastase activity from Staphylococcus epidermidis.

Authors:  P Teufel; F Götz
Journal:  J Bacteriol       Date:  1993-07       Impact factor: 3.490

Review 5.  Genetics of bacteriocins produced by lactic acid bacteria.

Authors:  T R Klaenhammer
Journal:  FEMS Microbiol Rev       Date:  1993-09       Impact factor: 16.408

6.  Isolation and characterization of the lantibiotic salivaricin A and its structural gene salA from Streptococcus salivarius 20P3.

Authors:  K F Ross; C W Ronson; J R Tagg
Journal:  Appl Environ Microbiol       Date:  1993-07       Impact factor: 4.792

7.  Characterization of the Lactococcus lactis nisin A operon genes nisP, encoding a subtilisin-like serine protease involved in precursor processing, and nisR, encoding a regulatory protein involved in nisin biosynthesis.

Authors:  J R van der Meer; J Polman; M M Beerthuyzen; R J Siezen; O P Kuipers; W M De Vos
Journal:  J Bacteriol       Date:  1993-05       Impact factor: 3.490

8.  Structure, organization, and expression of the lct gene for lacticin 481, a novel lantibiotic produced by Lactococcus lactis.

Authors:  J C Piard; O P Kuipers; H S Rollema; M J Desmazeaud; W M de Vos
Journal:  J Biol Chem       Date:  1993-08-05       Impact factor: 5.157

9.  Regulation of epidermin biosynthetic genes by EpiQ.

Authors:  A Peschel; J Augustin; T Kupke; S Stevanovic; F Götz
Journal:  Mol Microbiol       Date:  1993-07       Impact factor: 3.501

10.  Cloning, sequencing and production of the lantibiotic mersacidin.

Authors:  G Bierbaum; H Brötz; K P Koller; H G Sahl
Journal:  FEMS Microbiol Lett       Date:  1995-03-15       Impact factor: 2.742
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  20 in total

1.  Zn-dependent bifunctional proteases are responsible for leader peptide processing of class III lanthipeptides.

Authors:  Shaoming Chen; Bing Xu; Erquan Chen; Jiaqi Wang; Jingxia Lu; Stefano Donadio; Huiming Ge; Huan Wang
Journal:  Proc Natl Acad Sci U S A       Date:  2019-01-24       Impact factor: 11.205

2.  Activity of gallidermin on Staphylococcus aureus and Staphylococcus epidermidis biofilms.

Authors:  Jongkon Saising; Linda Dube; Anne-Kathrin Ziebandt; Supayang Piyawan Voravuthikunchai; Mulugeta Nega; Friedrich Götz
Journal:  Antimicrob Agents Chemother       Date:  2012-08-27       Impact factor: 5.191

3.  Production of the Bsa lantibiotic by community-acquired Staphylococcus aureus strains.

Authors:  Karen M Daly; Mathew Upton; Stephanie K Sandiford; Lorraine A Draper; Philip A Wescombe; Ralph W Jack; Paula M O'Connor; Angela Rossney; Friedrich Götz; Colin Hill; Paul D Cotter; R Paul Ross; John R Tagg
Journal:  J Bacteriol       Date:  2009-12-18       Impact factor: 3.490

4.  Biosynthesis of the antimicrobial peptide epilancin 15X and its N-terminal lactate.

Authors:  Juan E Velásquez; Xingang Zhang; Wilfred A van der Donk
Journal:  Chem Biol       Date:  2011-07-29

Review 5.  Coagulase-negative staphylococci.

Authors:  Karsten Becker; Christine Heilmann; Georg Peters
Journal:  Clin Microbiol Rev       Date:  2014-10       Impact factor: 26.132

6.  Dual role of GdmH in producer immunity and secretion of the Staphylococcal lantibiotics gallidermin and epidermin.

Authors:  M Hille; S Kies; F Götz; A Peschel
Journal:  Appl Environ Microbiol       Date:  2001-03       Impact factor: 4.792

7.  Synthesis and succinylation of subtilin-like lantibiotics are strongly influenced by glucose and transition state regulator AbrB.

Authors:  Sophie M Bochmann; Tobias Spieß; Peter Kötter; Karl-Dieter Entian
Journal:  Appl Environ Microbiol       Date:  2014-11-07       Impact factor: 4.792

8.  CylA is a sequence-specific protease involved in toxin biosynthesis.

Authors:  Weixin Tang; Silvia C Bobeica; Li Wang; Wilfred A van der Donk
Journal:  J Ind Microbiol Biotechnol       Date:  2018-11-27       Impact factor: 3.346

Review 9.  Interaction of host and Staphylococcus aureus protease-system regulates virulence and pathogenicity.

Authors:  Vigyasa Singh; Ujjal Jyoti Phukan
Journal:  Med Microbiol Immunol       Date:  2018-11-27       Impact factor: 3.402

10.  Structure and protective efficacy of the Staphylococcus aureus autocleaving protease EpiP.

Authors:  Misty L Kuhn; Prachi Prachi; George Minasov; Ludmilla Shuvalova; Jiapeng Ruan; Ievgeniia Dubrovska; James Winsor; Monica Giraldi; Massimiliano Biagini; Sabrina Liberatori; Silvana Savino; Fabio Bagnoli; Wayne F Anderson; Guido Grandi
Journal:  FASEB J       Date:  2014-01-13       Impact factor: 5.191
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