| Literature DB >> 853503 |
W J Gensler, C D Murthy, M H Trammell.
Abstract
To block epimerization and the resulting biological deactivation podophyllotoxin compounds, the lactone carbonyl group has been changed to methylene. Syntheses of several of these delactonized derivatives are described, all with modifications in the original lactone ring and some without the 4-hydroxyl group. Several biological assays show that most of the nonenolizable derivatives retain activity.Entities:
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Year: 1977 PMID： 853503 DOI： 10.1021/jm00215a004
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446