Literature DB >> 8528547

Protective effect of NO on gastric lesions and inhibition of expression of gastric inducible NOS by flurbiprofen and its nitro-derivative, nitroflurbiprofen.

S Mariotto1, M Menegazzi, A Carcereri de Prati, L Cuzzolin, A Adami, H Suzuki, G Benoni.   

Abstract

Nitroflurbiprofen (NFP) causes significantly less gastric lesions than flurbiprofen (FP), probably because of its capacity to release nitric oxide (NO) in the stomach. Lipopolysaccharide (LPS), which induces the expression of an inducible type of NO synthase (iNOS) in rat stomach, also reduces gastric mucosal damage elicited by FP. Furthermore, both FP and NFP decrease significantly the amount of mRNA encoding iNOS induced by LPS in the stomach. The inhibitory effect of NFP seems to be due at least in part to its ability to release NO.

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Year:  1995        PMID： 8528547      PMCID： PMC1909099          DOI： 10.1111/j.1476-5381.1995.tb16650.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  6 in total

1.  Inhibition by sodium nitroprusside of the expression of inducible nitric oxide synthase in rat neutrophils.

Authors:  S Mariotto; L Cuzzolin; A Adami; P Del Soldato; H Suzuki; G Benoni
Journal:  Br J Pharmacol       Date:  1995-03       Impact factor: 8.739

2.  Effect of a new non-steroidal anti-inflammatory drug, nitroflurbiprofen, on the expression of inducible nitric oxide synthase in rat neutrophils.

Authors:  S Mariotto; L Cuzzolin; A Adami; P Del Soldato; H Suzuki; G Benoni
Journal:  Br J Pharmacol       Date:  1995-05       Impact factor: 8.739

3.  Molecular cloning of a cDNA encoding an inducible calmodulin-dependent nitric-oxide synthase from rat liver and its expression in COS 1 cells.

Authors:  H Adachi; S Iida; S Oguchi; H Ohshima; H Suzuki; K Nagasaki; H Kawasaki; T Sugimura; H Esumi
Journal:  Eur J Biochem       Date:  1993-10-01

4.  Novel nonsteroidal anti-inflammatory drug derivatives with markedly reduced ulcerogenic properties in the rat.

Authors:  J L Wallace; B Reuter; C Cicala; W McKnight; M B Grisham; G Cirino
Journal:  Gastroenterology       Date:  1994-07       Impact factor: 22.682

Review 5.  Gastric ulceration: critical events at the neutrophil--endothelium interface.

Authors:  J L Wallace
Journal:  Can J Physiol Pharmacol       Date:  1993-01       Impact factor: 2.273

6.  Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.

Authors:  J M Chirgwin; A E Przybyla; R J MacDonald; W J Rutter
Journal:  Biochemistry       Date:  1979-11-27       Impact factor: 3.162
  6 in total
  5 in total

1.  Role of endogenous and exogenous nitric oxide on intestinal mucosa and microflora in the rat.

Authors:  L Cuzzolin; A Adami; F Crivellente; G Benoni
Journal:  Inflammation       Date:  1997-08       Impact factor: 4.092

2.  Study on paradoxical effects of NSAIDs on platelet activation.

Authors:  G Andrioli; S Lussignoli; S Gaino; G Benoni; P Bellavite
Journal:  Inflammation       Date:  1997-10       Impact factor: 4.092

3.  Flurbiprofen enantiomers inhibit inducible nitric oxide synthase expression in RAW 264.7 macrophages.

Authors:  B Hinz; K Brune; T Rau; A Pahl
Journal:  Pharm Res       Date:  2001-02       Impact factor: 4.200

4.  Vasorelaxant effect of nitric oxide releasing steroidal and nonsteroidal anti-inflammatory drugs.

Authors:  J Keeble; O A Al-Swayeh; P K Moore
Journal:  Br J Pharmacol       Date:  2001-08       Impact factor: 8.739

5.  NO-flurbiprofen reduces amyloid-beta, is neuroprotective in cell culture, and enhances cognition in response to cholinergic blockade.

Authors:  Samer O Abdul-Hay; Jia Luo; Rezene T Ashghodom; Gregory R J Thatcher
Journal:  J Neurochem       Date:  2009-08-21       Impact factor: 5.372
  5 in total

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