Literature DB >> 7545516

Effect of a new non-steroidal anti-inflammatory drug, nitroflurbiprofen, on the expression of inducible nitric oxide synthase in rat neutrophils.

S Mariotto1, L Cuzzolin, A Adami, P Del Soldato, H Suzuki, G Benoni.   

Abstract

The effects of a non-steroidal anti-inflammatory drug, flurbiprofen, and its nitro-derivative, nitroflurbiprofen, on inducible nitric oxide synthase in rat neutrophils were examined. Nitroflurbiprofen was shown to inhibit nitric oxide synthase induction caused by lipopolysaccharide administration, while flurbiprofen had no effect on nitric oxide synthase induction. This inhibitory action may be ascribed to nitric oxide released from nitroflurbiprofen.

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Year:  1995        PMID： 7545516      PMCID： PMC1908334          DOI： 10.1111/j.1476-5381.1995.tb15867.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  7 in total

1.  Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.

Authors:  D S Bredt; S H Snyder
Journal:  Proc Natl Acad Sci U S A       Date:  1990-01       Impact factor: 11.205

2.  Nitric oxide limits transcriptional induction of nitric oxide synthase in CNS glial cells.

Authors:  S K Park; H L Lin; S Murphy
Journal:  Biochem Biophys Res Commun       Date:  1994-06-15       Impact factor: 3.575

3.  The induction of nitric oxide synthase and intestinal vascular permeability by endotoxin in the rat.

Authors:  N K Boughton-Smith; S M Evans; F Laszlo; B J Whittle; S Moncada
Journal:  Br J Pharmacol       Date:  1993-11       Impact factor: 8.739

4.  A rapid method for the assay of nitrate in urine using the nitrate reductase enzyme of Escherichia coli.

Authors:  B Bartholomew
Journal:  Food Chem Toxicol       Date:  1984-07       Impact factor: 6.023

5.  Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids.

Authors:  L C Green; D A Wagner; J Glogowski; P L Skipper; J S Wishnok; S R Tannenbaum
Journal:  Anal Biochem       Date:  1982-10       Impact factor: 3.365

6.  Feedback inhibition of nitric oxide synthase activity by nitric oxide.

Authors:  J Assreuy; F Q Cunha; F Y Liew; S Moncada
Journal:  Br J Pharmacol       Date:  1993-03       Impact factor: 8.739

7.  Novel nonsteroidal anti-inflammatory drug derivatives with markedly reduced ulcerogenic properties in the rat.

Authors:  J L Wallace; B Reuter; C Cicala; W McKnight; M B Grisham; G Cirino
Journal:  Gastroenterology       Date:  1994-07       Impact factor: 22.682
  7 in total
  9 in total

1.  Flurbiprofen enantiomers inhibit inducible nitric oxide synthase expression in RAW 264.7 macrophages.

Authors:  B Hinz; K Brune; T Rau; A Pahl
Journal:  Pharm Res       Date:  2001-02       Impact factor: 4.200

2.  Nitroparacetamol exhibits anti-inflammatory and anti-nociceptive activity.

Authors:  O A al-Swayeh; L E Futter; R H Clifford; P K Moore
Journal:  Br J Pharmacol       Date:  2000-08       Impact factor: 8.739

Review 3.  Pharmacology and potential therapeutic applications of nitric oxide-releasing non-steroidal anti-inflammatory and related nitric oxide-donating drugs.

Authors:  J E Keeble; P K Moore
Journal:  Br J Pharmacol       Date:  2002-10       Impact factor: 8.739

4.  Nitroaspirin corrects immune dysfunction in tumor-bearing hosts and promotes tumor eradication by cancer vaccination.

Authors:  Carmela De Santo; Paolo Serafini; Ilaria Marigo; Luigi Dolcetti; Manlio Bolla; Piero Del Soldato; Cecilia Melani; Cristiana Guiducci; Mario P Colombo; Manuela Iezzi; Piero Musiani; Paola Zanovello; Vincenzo Bronte
Journal:  Proc Natl Acad Sci U S A       Date:  2005-03-07       Impact factor: 11.205

5.  Protective effect of NO on gastric lesions and inhibition of expression of gastric inducible NOS by flurbiprofen and its nitro-derivative, nitroflurbiprofen.

Authors:  S Mariotto; M Menegazzi; A Carcereri de Prati; L Cuzzolin; A Adami; H Suzuki; G Benoni
Journal:  Br J Pharmacol       Date:  1995-09       Impact factor: 8.739

6.  Nitric oxide-releasing flurbiprofen reduces formation of proinflammatory hydrogen sulfide in lipopolysaccharide-treated rat.

Authors:  Farhana Anuar; Matthew Whiteman; Jia Ling Siau; Shing Erl Kwong; Madhav Bhatia; Philip K Moore
Journal:  Br J Pharmacol       Date:  2006-04       Impact factor: 8.739

7.  Inhibition of inducible nitric oxide synthase expression by novel nonsteroidal anti-inflammatory derivatives with gastrointestinal-sparing properties.

Authors:  G Cirino; C P Wheeler-Jones; J L Wallace; P Del Soldato; A R Baydoun
Journal:  Br J Pharmacol       Date:  1996-04       Impact factor: 8.739

8.  Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells.

Authors:  Barbara Molon; Stefano Ugel; Federica Del Pozzo; Cristiana Soldani; Serena Zilio; Debora Avella; Antonella De Palma; Pierluigi Mauri; Ana Monegal; Maria Rescigno; Benedetta Savino; Piergiuseppe Colombo; Nives Jonjic; Sanja Pecanic; Loretta Lazzarato; Roberta Fruttero; Alberto Gasco; Vincenzo Bronte; Antonella Viola
Journal:  J Exp Med       Date:  2011-09-19       Impact factor: 14.307

Review 9.  The emerging immunological role of post-translational modifications by reactive nitrogen species in cancer microenvironment.

Authors:  Francesco De Sanctis; Sara Sandri; Giovanna Ferrarini; Irene Pagliarello; Silvia Sartoris; Stefano Ugel; Ilaria Marigo; Barbara Molon; Vincenzo Bronte
Journal:  Front Immunol       Date:  2014-02-24       Impact factor: 7.561
  9 in total

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