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Literature DB >> 8528160

The mathematics of radiation target analyses.

Abstract

Radiation target theory has been extended to complex biochemical systems. Mathematical analyses are presented for multiple forms of biological active proteins, for the presence of large inhibitors or activators, for compounds which regulate rate or affinity and for multiple-step reactions. Several predictions of these models have been verified experimentally.

Mesh：

Year: 1995 PMID： 8528160 DOI： 10.1007/bf02458298

Source DB: PubMed Journal: Bull Math Biol ISSN： 0092-8240 Impact factor: 1.758

21 in total

1. Effect of subunit interactions on enzymatic activity of glutathione S-transferases: a radiation inactivation study.

Authors: T D Boyer; E S Kempner
Journal: Anal Biochem Date: 1992-11-15 Impact factor: 3.365

2. Activation of adenylate cyclase in hepatic membranes involves interactions of the catalytic unit with multimeric complexes of regulatory proteins.

Authors: W Schlegel; E S Kempner; M Rodbell
Journal: J Biol Chem Date: 1979-06-25 Impact factor: 5.157

3. The functional size of acyl-coenzyme A (CoA):cholesterol acyltransferase and acyl-CoA hydrolase as determined by radiation inactivation.

Authors: J T Billheimer; D A Cromley; E S Kempner
Journal: J Biol Chem Date: 1990-05-25 Impact factor: 5.157

The mathematics of radiation target analyses.

1. Effect of subunit interactions on enzymatic activity of glutathione S-transferases: a radiation inactivation study.

2. Activation of adenylate cyclase in hepatic membranes involves interactions of the catalytic unit with multimeric complexes of regulatory proteins.

3. The functional size of acyl-coenzyme A (CoA):cholesterol acyltransferase and acyl-CoA hydrolase as determined by radiation inactivation.

4. In situ structural analysis of microsomal UDP-glucuronyltransferases by radiation inactivation.

5. Inactivation of macromolecules by ionizing radiation. Deterministic single-hit or stochastic multievent process?

Review 6. The radiation inactivation method as a tool to study structure-function relationships in proteins.

7. A monomeric protein in the Golgi membrane catalyzes both N-deacetylation and N-sulfation of heparan sulfate.

Review 8. Damage to proteins due to the direct action of ionizing radiation.

9. Radiation inactivation of oligomeric enzyme systems: theoretical considerations.

10. Radiation inactivation reveals discrete cation binding sites that modulate dihydropyridine binding sites.

1. Radiation inactivation of ribonucleotide reductase, an enzyme with a stable free radical.

2. Direct radiation damage is confined to a single polypeptide in rabbit immunoglobulin G.

3. Structure-activity relationships in HIV-1 reverse transcriptase revealed by radiation target analysis.

4. Radiation target analyses of DNA template/primer complexes.

5. A radiation target method for size determination of supercoiled plasmid DNA.