Literature DB >> 12668485

Direct radiation damage is confined to a single polypeptide in rabbit immunoglobulin G.

J H Miller1, L R Draper, E S Kempner.   

Abstract

Frozen rabbit immunoglobulin G was exposed to high-energy electrons. The surviving polypeptide subunits were determined and analyzed by radiation target analysis. Each subunit was independently damaged by radiation whether or not they were bound by disulfide bridges to other subunits, demonstrating that in IgG radiation-deposited energy did not travel across disulfide bonds.

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Year:  2003        PMID： 12668485      PMCID： PMC1302843          DOI： 10.1016/S0006-3495(03)75082-6

Source DB:  PubMed          Journal:  Biophys J        ISSN： 0006-3495            Impact factor:   4.033


  13 in total

1.  THE ARRANGEMENT OF THE PEPTIDE CHAINS IN GAMMA-GLOBULIN.

Authors:  J B FLEISCHMAN; R R PORTER; E M PRESS
Journal:  Biochem J       Date:  1963-08       Impact factor: 3.857

2.  Effects of ionizing radiations on proteins. Evidence of non-random fragmentations and a caution in the use of the method for determination of molecular mass.

Authors:  M Le Maire; L Thauvette; B de Foresta; A Viel; G Beauregard; M Potier
Journal:  Biochem J       Date:  1990-04-15       Impact factor: 3.857

3.  Radiation inactivation of ricin occurs with transfer of destructive energy across a disulfide bridge.

Authors:  H T Haigler; D J Woodbury; E S Kempner
Journal:  Proc Natl Acad Sci U S A       Date:  1985-08       Impact factor: 11.205

4.  The disulphide bonds of the heavy chain of rabbit immunoglobulin G.

Authors:  I J O'Donnell; B Frangione; R R Porter
Journal:  Biochem J       Date:  1970-01       Impact factor: 3.857

5.  Characterization of a human macroglobulin. II. Distribution of the disulfide bonds.

Authors:  F Miller; H Metzger
Journal:  J Biol Chem       Date:  1965-12       Impact factor: 5.157

6.  Determination of the oligomeric structure of the Ca2+ pump protein in canine cardiac sarcoplasmic reticulum membranes using radiation inactivation analysis.

Authors:  B K Chamberlain; C J Berenski; C Y Jung; S Fleischer
Journal:  J Biol Chem       Date:  1983-10-10       Impact factor: 5.157

7.  Target size of D-beta-hydroxybutyrate dehydrogenase. Functional and structural molecular weight based on radiation inactivation.

Authors:  J O McIntyre; P Churchill; A Maurer; C J Berenski; C Y Jung; S Fleischer
Journal:  J Biol Chem       Date:  1983-01-25       Impact factor: 5.157

8.  Molecular weight determinations from radiation inactivation.

Authors:  J T Harmon; T B Nielsen; E S Kempner
Journal:  Methods Enzymol       Date:  1985       Impact factor: 1.600

9.  Structural characteristics of hemolytic antibodies as determined by the effects of ionizing radiation.

Authors:  W F Rosse; H J Rapp; T Borsos
Journal:  J Immunol       Date:  1967-06       Impact factor: 5.422

10.  Unexpected findings from target analysis of immunoglobulin E and its receptor.

Authors:  C Fewtrell; E Kempner; G Poy; H Metzger
Journal:  Biochemistry       Date:  1981-11-10       Impact factor: 3.162
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  1 in total

1.  The ubiquitin-protein ligase Nedd4-2 differentially interacts with and regulates members of the Tweety family of chloride ion channels.

Authors:  Yaowu He; Deanne H Hryciw; Melanie L Carroll; Stephen A Myers; Astrid K Whitbread; Sharad Kumar; Philip Poronnik; John D Hooper
Journal:  J Biol Chem       Date:  2008-06-24       Impact factor: 5.157
  1 in total

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