Literature DB >> 8522324

Localization of the CDKN4/p27Kip1 gene to human chromosome 12p12.3.

E Martin1, V Cacheux, H Cavé, J M Lapierre, D Le Paslier, B Grandchamp.   

Abstract

CDKN4/p27Kip1 is a cyclin-dependent kinase (Cdk) inhibitor implicated in G1 phase arrest, which negatively regulates G1 phase progression in response to TGF beta, and might represent a tumor suppressor gene. We report here the chromosomal assignment of the human CDKN4 gene to chromosome 12p12.3 in close proximity to highly polymorphic microsatellite markers.

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Year:  1995        PMID： 8522324     DOI： 10.1007/bf00210296

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  15 in total

1.  The 1993-94 Généthon human genetic linkage map.

Authors:  G Gyapay; J Morissette; A Vignal; C Dib; C Fizames; P Millasseau; S Marc; G Bernardi; M Lathrop; J Weissenbach
Journal:  Nat Genet       Date:  1994-06       Impact factor: 38.330

2.  Detection of single-copy genes by nonisotopic in situ hybridization on human chromosomes.

Authors:  D Cherif; O Bernard; R Berger
Journal:  Hum Genet       Date:  1989-03       Impact factor: 4.132

3.  p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest.

Authors:  K Polyak; J Y Kato; M J Solomon; C J Sherr; J Massague; J M Roberts; A Koff
Journal:  Genes Dev       Date:  1994-01       Impact factor: 11.361

4.  p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21.

Authors:  H Toyoshima; T Hunter
Journal:  Cell       Date:  1994-07-15       Impact factor: 41.582

5.  A novel inhibitor of cyclin-Cdk activity detected in transforming growth factor beta-arrested epithelial cells.

Authors:  J M Slingerland; L Hengst; C H Pan; D Alexander; M R Stampfer; S I Reed
Journal:  Mol Cell Biol       Date:  1994-06       Impact factor: 4.272

6.  Loss of heterozygosity and homozygous deletions on 9p21-22 in melanoma.

Authors:  E A Holland; S C Beaton; B G Edwards; R F Kefford; G J Mann
Journal:  Oncogene       Date:  1994-05       Impact factor: 9.867

7.  Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers.

Authors:  T Nobori; K Miura; D J Wu; A Lois; K Takabayashi; D A Carson
Journal:  Nature       Date:  1994-04-21       Impact factor: 49.962

8.  Fluorescence in situ hybridization mapping of translocations and deletions involving the short arm of human chromosome 12 in malignant hematologic diseases.

Authors:  H Kobayashi; K T Montgomery; S K Bohlander; C N Adra; B L Lim; R S Kucherlapati; H Donis-Keller; M S Holt; M M Le Beau; J D Rowley
Journal:  Blood       Date:  1994-11-15       Impact factor: 22.113

9.  Cytogenetic analysis using quantitative, high-sensitivity, fluorescence hybridization.

Authors:  D Pinkel; T Straume; J W Gray
Journal:  Proc Natl Acad Sci U S A       Date:  1986-05       Impact factor: 11.205

10.  p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest.

Authors:  G J Hannon; D Beach
Journal:  Nature       Date:  1994-09-15       Impact factor: 49.962
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  1 in total

1.  Predictive value of decreased p27Kip1 protein expression for the recurrence-free and long-term survival of prostate cancer patients.

Authors:  M Kuczyk; S Machtens; K Hradil; J Schubach; W Christian; R Knüchel; J Hartmann; C Bokemeyer; U Jonas; J Serth
Journal:  Br J Cancer       Date:  1999-11       Impact factor: 7.640
  1 in total

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