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Literature DB >> 8078588

p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest.

Abstract

Transforming growth factor-beta (TGF-beta) inhibits cell proliferation by inducing a G1-phase cell cycle arrest. Normal progression through G1 is promoted by the activity of the cyclin-dependent protein kinases CDK4 and CDK6 (ref. 2), which are inhibited by the protein p16INK4. We have isolated a new member of the p16INK4 family, p15INK4B. p15 expression is induced approximately 30-fold in human keratinocytes by treatment with TGF-beta, suggesting that p15 may act as an effector of TGF-beta-mediated cell cycle arrest. The gene encoding p15 is located on chromosome 9 adjacent to the p16 gene at a frequent site of chromosomal abnormality in human tumours (9p21).

Entities: Disease Gene Species

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Year: 1994 PMID： 8078588 DOI： 10.1038/371257a0

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

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Cited

479 in total

1. PTGF-beta, a type beta transforming growth factor (TGF-beta) superfamily member, is a p53 target gene that inhibits tumor cell growth via TGF-beta signaling pathway.

Authors: M Tan; Y Wang; K Guan; Y Sun
Journal: Proc Natl Acad Sci U S A Date: 2000-01-04 Impact factor: 11.205

2. A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras.

Authors: M Kretzschmar; J Doody; I Timokhina; J Massagué
Journal: Genes Dev Date: 1999-04-01 Impact factor: 11.361

3. Hepatocyte growth factor releases mink epithelial cells from transforming growth factor beta1-induced growth arrest by restoring Cdk6 expression and cyclin E-associated Cdk2 activity.

Authors: M Tsubari; J Taipale; E Tiihonen; J Keski-Oja; M Laiho
Journal: Mol Cell Biol Date: 1999-05 Impact factor: 4.272

p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest.

1. PTGF-beta, a type beta transforming growth factor (TGF-beta) superfamily member, is a p53 target gene that inhibits tumor cell growth via TGF-beta signaling pathway.

2. A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras.

3. Hepatocyte growth factor releases mink epithelial cells from transforming growth factor beta1-induced growth arrest by restoring Cdk6 expression and cyclin E-associated Cdk2 activity.

Review 4. Cell cycle checkpoints and their inactivation in human cancer.

5. Overexpression of p27(KIP1) induced cell cycle arrest in G(1) phase and subsequent apoptosis in HCC-9204 cell line.

6. Polymorphism of p16INK4a gene and rare mutation of p15INK4b gene exon2 in primary hepatocarcinoma.

7. Identification of uncommon chromosomal aberrations in the neuroglioma cell line H4 by spectral karyotyping.

8. CAK-independent activation of CDK6 by a viral cyclin.

Review 9. Strategies in subversion: de-regulation of the mammalian cell cycle by viral gene products.

10. Dynamic DNA methylation change in the CpG island region of p15 during human myeloid development.