Literature DB >> 8517715

Effects of probenecid on the pharmacokinetics of allopurinol riboside.

J B Were1, T A Shapiro.   

Abstract

Allopurinol riboside is an experimental agent for the treatment of leishmaniasis and American trypanosomiasis. Previous studies showed that after oral administration, unexpectedly low levels of allopurinol riboside in plasma are attributable to incomplete absorption and rapid renal clearance. In this randomized, crossover evaluation in healthy volunteers, probenecid reduces the renal clearance of allopurinol riboside, extends the half-life of allopurinol riboside in plasma, and triples the levels of allopurinol riboside in plasma.

Entities:  

Mesh：

Substances：

Year:  1993        PMID： 8517715      PMCID： PMC187932          DOI： 10.1128/AAC.37.5.1193

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  17 in total

1.  Prediction of creatinine clearance from serum creatinine.

Authors:  D W Cockcroft; M H Gault
Journal:  Nephron       Date:  1976       Impact factor: 2.847

2.  Urinary excretion of purines, pyrimidines and pyrazolopyrimidines in patients treated with allopurinol or oxipurinol.

Authors:  H A Simmonds
Journal:  Clin Chim Acta       Date:  1969-02       Impact factor: 3.786

3.  Antileishmanial effect of allopurinol and allopurinol ribonucleoside on intracellular forms of Leishmania donovani.

Authors:  R L Berens; J J Marr; D J Nelson; S W LaFon
Journal:  Biochem Pharmacol       Date:  1980-09-01       Impact factor: 5.858

4.  Allopurinol ribonucleoside as an antileishmanial agent. Biological effects, metabolism, and enzymatic phosphorylation.

Authors:  D J Nelson; S W LaFon; J V Tuttle; W H Miller; R L Miller; T A Krenitsky; G B Elion; R L Berens; J J Marr
Journal:  J Biol Chem       Date:  1979-11-25       Impact factor: 5.157

5.  Antileishmanial effect of allopurinol. II. Relationship of adenine metabolism in Leishmania species to the action of allopurinol.

Authors:  J J Marr; R L Berens
Journal:  J Infect Dis       Date:  1977-12       Impact factor: 5.226

6.  Metabolic studies of allopurinol, an inhibitor of xanthine oxidase.

Authors:  G B Elion; A Kovensky; G H Hitchings
Journal:  Biochem Pharmacol       Date:  1966-07       Impact factor: 5.858

7.  Pharmacokinetics and metabolism of allopurinol riboside.

Authors:  T A Shapiro; J B Were; K Danso; D J Nelson; R E Desjardins; C L Pamplin
Journal:  Clin Pharmacol Ther       Date:  1991-05       Impact factor: 6.875

8.  Antitrypanosomal effect of allopurinol: conversion in vivo to aminopyrazolopyrimidine nucleotides by Trypanosoma curzi.

Authors:  J J Marr; R L Berens; D J Nelson
Journal:  Science       Date:  1978-09-15       Impact factor: 47.728

9.  Metabolism of pyrazolo(3,4-d)pyrimidines in Leishmania braziliensis and Leishmania donovani. Allopurinol, oxipurinol, and 4-aminopyrazolo(3,4-d)pyrimidine.

Authors:  D J Nelson; C J Bugge; G B Elion; R L Berens; J J Marr
Journal:  J Biol Chem       Date:  1979-05-25       Impact factor: 5.157

Review 10.  Clinical pharmacokinetics of probenecid.

Authors:  R F Cunningham; Z H Israili; P G Dayton
Journal:  Clin Pharmacokinet       Date:  1981 Mar-Apr       Impact factor: 6.447
View more
  1 in total

Review 1.  Lack of Clinical Pharmacokinetic Studies to Optimize the Treatment of Neglected Tropical Diseases: A Systematic Review.

Authors:  Luka Verrest; Thomas P C Dorlo
Journal:  Clin Pharmacokinet       Date:  2017-06       Impact factor: 6.447
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.