Literature DB >> 356267

Antitrypanosomal effect of allopurinol: conversion in vivo to aminopyrazolopyrimidine nucleotides by Trypanosoma curzi.

J J Marr, R L Berens, D J Nelson.   

Abstract

The parasite Trypanosoma cruzi metabolizes allopurinol by a sequential conversion to allopurinol mononucleotide and aminopurinol mononucleotide. The latter is incorporated into RNA. This transformation of a widely used innocuous agent, allopurinol, into a toxic adenine analog appears to account for the antiprotozoan effect of allopurinol. These unique enzymatic activities appear to occur only in T. cruzi and the pathogenic lesihaminae. Allopurinol may serve as a model for the synthesis of similar antiprotozoan agents.

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Year:  1978        PMID： 356267     DOI： 10.1126/science.356267

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  20 in total

1.  Nobel lecture in physiology or medicine--1988. The purine path to chemotherapy.

Authors:  G B Elion
Journal:  In Vitro Cell Dev Biol       Date:  1989-04

2.  Biological action of inosine analogs in Leishmania and Trypanosoma spp.

Authors:  J J Marr; R L Berens; N K Cohn; D J Nelson; R S Klein
Journal:  Antimicrob Agents Chemother       Date:  1984-02       Impact factor: 5.191

Review 3.  Tropical diseases encountered in Canada: 1. Chagas' disease.

Authors:  H Schipper; B M McClarty; K E McRuer; R A Nash; C J Penney
Journal:  Can Med Assoc J       Date:  1980-01-26       Impact factor: 8.262

4.  Pyrimidine metabolism in Tritrichomonas foetus.

Authors:  C C Wang; R Verham; S F Tzeng; S Aldritt; H W Cheng
Journal:  Proc Natl Acad Sci U S A       Date:  1983-05       Impact factor: 11.205

Review 5.  A re-evaluation of the tissue distribution and physiology of xanthine oxidoreductase.

Authors:  A Kooij
Journal:  Histochem J       Date:  1994-12

6.  Analysis of cDNA encoding the hypoxanthine-guanine phosphoribosyltransferase (HGPRTase) of Schistosoma mansoni; a putative target for chemotherapy.

Authors:  S P Craig; J H McKerrow; G R Newport; C C Wang
Journal:  Nucleic Acids Res       Date:  1988-07-25       Impact factor: 16.971

7.  Effect of allopurinol on Trypanosoma cruzi: metabolism and biological activity in intracellular and bloodstream forms.

Authors:  R L Berens; J J Marr; F S Steele da Cruz; D J Nelson
Journal:  Antimicrob Agents Chemother       Date:  1982-10       Impact factor: 5.191

8.  Molecular biology studies of tubercidin resistance in Trypanosoma cruzi.

Authors:  T Nozaki; J A Dvorak
Journal:  Parasitol Res       Date:  1993       Impact factor: 2.289

9.  In vitro and in vivo activities of formycin B against Trypanosoma cruzi.

Authors:  R E McCabe; J S Remington; F G Araujo
Journal:  Antimicrob Agents Chemother       Date:  1985-04       Impact factor: 5.191

10.  Purine metabolism in the protozoan parasite Eimeria tenella.

Authors:  C C Wang; P M Simashkevich
Journal:  Proc Natl Acad Sci U S A       Date:  1981-11       Impact factor: 11.205
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