Literature DB >> 851032

Establishment and characteristics of a human pancreatic cancer cell line (HCG-25).

T Akagi, T Kimoto.   

Abstract

A floating cell line (HCG-25) was established from the metastatic ascitic fluid of a human pancreatic adenocarcinoma of ductal cell origin. The cell line was characterized by the growth in suspension with a doubling time of 15.6 hr, a high cloning efficiency in soft agar and a modal chromosome number of 72. Electron microscopic examination revealed terminal bars in a small number of cells. Production of mucin and immunoglobulins and phagocytosis were not demonstrated. Heterotransplantation of the cells produced tumors, being undifferentiated carcinoma histologically. These characteristics mentioned above confirm that HGC-25 cell line is a human pancreatic cancer cell line.

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Mesh：

Year:  1977        PMID： 851032     DOI： 10.1111/j.1440-1827.1977.tb01859.x

Source DB:  PubMed          Journal:  Acta Pathol Jpn        ISSN： 0001-6632


  11 in total

1.  Monoclonal antibody to a human pancreatic carcinoma cell line recognizes gastrointestinal neoplasms.

Authors:  H J Kahn; H Yeger; R Loftus; M H Goldrosen
Journal:  Am J Pathol       Date:  1989-03       Impact factor: 4.307

2.  Radioimmunoscintigraphy of human pancreatic carcinoma xenografts in nude mice with 131I-labeled monoclonal antibody.

Authors:  T Tsuda; H Koshiba; T Usui; M Kubota; K Kikuchi; K Morita
Journal:  Ann Nucl Med       Date:  1990-07       Impact factor: 2.668

3.  Establishment and characterization of a carcinoembryonic antigen producing cell line derived from human pancreatic exocrine cancer.

Authors:  N Yamaguchi; G Uozumi; H Ikeuchi; H Morioka; M Machino; K Kawai
Journal:  Gastroenterol Jpn       Date:  1983-12

4.  Establishment and characterization of a new transplantable pancreatic cancer xenograft (PZX-5) in immunosuppressed mice.

Authors:  A Zalatnai; J Bocsi; F Timár; I Babó
Journal:  Int J Pancreatol       Date:  1998-02

5.  A new human pancreatic carcinoma cell line developed for adoptive immunotherapy studies with lymphokine-activated killer cells in nude mice.

Authors:  B J Drucker; F M Marincola; D Y Siao; T A Donlon; C D Bangs; W D Holder
Journal:  In Vitro Cell Dev Biol       Date:  1988-12

6.  Bone morphogenetic proteins induce pancreatic cancer cell invasiveness through a Smad1-dependent mechanism that involves matrix metalloproteinase-2.

Authors:  Kelly J Gordon; Kellye C Kirkbride; Tam How; Gerard C Blobe
Journal:  Carcinogenesis       Date:  2008-12-04       Impact factor: 4.944

7.  Human pancreatic adenocarcinoma: in vitro and in vivo morphology of a new tumor line established from ascites.

Authors:  W H Chen; J S Horoszewicz; S S Leong; T Shimano; R Penetrante; W H Sanders; R Berjian; H O Douglass; E W Martin; T M Chu
Journal:  In Vitro       Date:  1982-01

8.  Characterization of three cloned cell lines from a N-nitrosobis(2-hydroxypropyl)amine-induced transplantable hamster pancreatic ductal adenocarcinoma.

Authors:  T Mori; M Tsutsumi; O Noguchi; K Horiguchi; K Hohnoki; S Okita; F Suzuki; Y Konishi
Journal:  Int J Pancreatol       Date:  1994 Oct-Dec

9.  Identification of a human T cell clone with the cytotoxic T lymphocyte and natural killer-like cytotoxic function against autologous mammary carcinoma and K562 line.

Authors:  T Sato; M Okubo; Y Wada; N Sato; K Kikuchi
Journal:  Jpn J Cancer Res       Date:  1989-07

10.  Establishment and characterization of primary human pancreatic carcinoma in continuous cell culture and in nude mice.

Authors:  A G Grant; D Duke; J Hermon-Taylor
Journal:  Br J Cancer       Date:  1979-02       Impact factor: 7.640
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