Literature DB >> 2223381

Radioimmunoscintigraphy of human pancreatic carcinoma xenografts in nude mice with 131I-labeled monoclonal antibody.

T Tsuda1, H Koshiba, T Usui, M Kubota, K Kikuchi, K Morita.   

Abstract

Encouraged by reports of radioimmunoimaging of colorectal carcinomas and by examining an immunohistochemical report on resected pancreas cancer tissues, we studied the diagnostic potential of radioimmunoimaging with the radioiodinelabeled monoclonal antibody to the surface antigen of a pancreas cancer cell line. A monoclonal antibody (MoAb; HC-1) to a human pancreas cancer cell line (HGC25)5 was labeled with radioiodine and injected into athymic nude mice implanted with human pancreas cancer cells. Antibody HC-1 was cleared from the circulation and accumulated significantly in the implanted tumor sites.

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Year:  1990        PMID： 2223381     DOI： 10.1007/bf03164599

Source DB:  PubMed          Journal:  Ann Nucl Med        ISSN： 0914-7187            Impact factor:   2.668


  15 in total

1.  Isolation of pure IgG1, IgG2a and IgG2b immunoglobulins from mouse serum using protein A-sepharose.

Authors:  P L Ey; S J Prowse; C R Jenkin
Journal:  Immunochemistry       Date:  1978-07

2.  Effect of DTPA conjugation on the antigen binding activity and biodistribution of monoclonal antibodies against alpha-fetoprotein.

Authors:  H Sakahara; K Endo; T Nakashima; M Koizumi; H Ohta; K Torizuka; T Furukawa; Y Ohmomo; A Yokoyama; K Okada
Journal:  J Nucl Med       Date:  1985-07       Impact factor: 10.057

3.  Radioactive labeling of antibody: a simple and efficient method.

Authors:  D J Hnatowich; W W Layne; R L Childs; D Lanteigne; M A Davis; T W Griffin; P W Doherty
Journal:  Science       Date:  1983-05-06       Impact factor: 47.728

4.  High-specific-activity 111In-labeled anticarcinoembryonic antigen monoclonal antibody: biodistribution and imaging in nude mice bearing human colon cancer xenografts.

Authors:  J G Jakowatz; B G Beatty; W G Vlahos; D Porudominsky; V J Philben; L E Williams; R J Paxton; J E Shively; J D Beatty
Journal:  Cancer Res       Date:  1985-11       Impact factor: 12.701

5.  Specific antigen in serum of patients with colon carcinoma.

Authors:  H Koprowski; M Herlyn; Z Steplewski; H F Sears
Journal:  Science       Date:  1981-04-03       Impact factor: 47.728

6.  Metastatic colon carcinoma detected with radiolabeled F(ab')2 monoclonal antibody fragments.

Authors:  P J Moldofsky; J Powe; C B Mulhern; N Hammond; H F Sears; R A Gatenby; Z Steplewski; H Koprowski
Journal:  Radiology       Date:  1983-11       Impact factor: 11.105

7.  Antigens of human pancreatic adenocarcinoma cells defined by murine monoclonal antibodies.

Authors:  R S Metzgar; M T Gaillard; S J Levine; F L Tuck; E H Bossen; M J Borowitz
Journal:  Cancer Res       Date:  1982-02       Impact factor: 12.701

8.  Prolonged binding of a radiolabeled monoclonal antibody (B72.3) used for the in situ radioimmunodetection of human colon carcinoma xenografts.

Authors:  D Colcher; A M Keenan; S M Larson; J Schlom
Journal:  Cancer Res       Date:  1984-12       Impact factor: 12.701

9.  Establishment and characteristics of a human pancreatic cancer cell line (HCG-25).

Authors:  T Akagi; T Kimoto
Journal:  Acta Pathol Jpn       Date:  1977-01

10.  Radiolabeled fragments of monoclonal antibodies against carcinoembryonic antigen for localization of human colon carcinoma grafted into nude mice.

Authors:  F Buchegger; C M Haskell; M Schreyer; B R Scazziga; S Randin; S Carrel; J P Mach
Journal:  J Exp Med       Date:  1983-08-01       Impact factor: 14.307
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  3 in total

1.  The effect of radioimmunotherapy using murine monoclonal antibody KIS1 on esophageal squamous cell carcinoma-bearing nude mice.

Authors:  T Fujii; H Yamana; Y Toh; U Toh; H Fujita; K Shirouzu; M Morimatsu
Journal:  Surg Today       Date:  1997       Impact factor: 2.549

2.  In vitro reactivity and in vivo biodistribution of the monoclonal antibody A7 using human gastric carcinoma cell lines.

Authors:  N Yamaoka; T Yamaguchi; E Otsuji; M Kato; T Kotani; K Kitamura; T Takahashi
Journal:  Br J Cancer       Date:  1994-09       Impact factor: 7.640

3.  Enhanced tumor localization of radiolabeled Fab fragments of monoclonal antibody A7 in nude mice bearing human pancreatic carcinoma xenografts.

Authors:  E Otsuji; T Yamaguchi; N Yamaoka; M Kato; T Kotani; K Kitamura; N Yamaguchi; T Takahashi
Journal:  Jpn J Cancer Res       Date:  1993-08
  3 in total

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