Literature DB >> 8509340

Transcriptional analysis of the Streptomyces glaucescens tetracenomycin C biosynthesis gene cluster.

H Decker1, C R Hutchinson.   

Abstract

A 12.6-kb DNA fragment from Streptomyces glaucescens GLA.0 containing the 12 genes for tetracenomycin (TCM) C biosynthesis and resistance enabled Streptomyces lividans to produce TCM C. Transcriptional analysis of the tcmPG intergenic region in this cluster established the presence of two divergent promoters. The tcmIc mutation, a T-to-G transversion in the -10 region of the tcmG promoter, decreased promoter activity drastically at the stationary growth stage and time of maximum TCM C accumulation. This promoter may direct the transcription of a tcmGHIJKLMNO operon, while the other promoter is for tcmP.

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Year:  1993        PMID： 8509340      PMCID： PMC204805          DOI： 10.1128/jb.175.12.3887-3892.1993

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  33 in total

Review 1.  Nucleoside phosphorothioates.

Authors:  F Eckstein
Journal:  Annu Rev Biochem       Date:  1985       Impact factor: 23.643

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Journal:  Eur J Biochem       Date:  1971-06-11

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Authors:  J Brosius; R L Cate; A P Perlmutter
Journal:  J Biol Chem       Date:  1982-08-10       Impact factor: 5.157

Review 4.  Compilation and analysis of Escherichia coli promoter DNA sequences.

Authors:  D K Hawley; W R McClure
Journal:  Nucleic Acids Res       Date:  1983-04-25       Impact factor: 16.971

5.  Adrenergic and cholinergic receptors of cerebral microvessels.

Authors:  S I Harik; V K Sharma; J R Wetherbee; R H Warren; S P Banerjee
Journal:  J Cereb Blood Flow Metab       Date:  1981       Impact factor: 6.200

6.  Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors.

Authors:  C Yanisch-Perron; J Vieira; J Messing
Journal:  Gene       Date:  1985       Impact factor: 3.688

7.  [Metabolic products of microorganisms. 175. Tetracenomycin C (author's transl)].

Authors:  W Weber; H Zähner; J Siebers; K Schröder; A Zeeck
Journal:  Arch Microbiol       Date:  1979-05       Impact factor: 2.552

8.  Isolation of tetracenomycin C-nonproducing Streptomyces glaucescens mutants.

Authors:  H Motamedi; E Wendt-Pienkowski; C R Hutchinson
Journal:  J Bacteriol       Date:  1986-08       Impact factor: 3.490

9.  Chromogenic identification of genetic regulatory signals in Bacillus subtilis based on expression of a cloned Pseudomonas gene.

Authors:  M M Zukowski; D F Gaffney; D Speck; M Kauffmann; A Findeli; A Wisecup; J P Lecocq
Journal:  Proc Natl Acad Sci U S A       Date:  1983-02       Impact factor: 11.205

10.  Nucleotide sequences and heterologous expression of tcmG and tcmP, biosynthetic genes for tetracenomycin C in Streptomyces glaucescens.

Authors:  H Decker; H Motamedi; C R Hutchinson
Journal:  J Bacteriol       Date:  1993-06       Impact factor: 3.490
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  4 in total

1.  The Streptomyces galP1 promoter has a novel RNA polymerase recognition sequence and is transcribed by a new form of RNA polymerase in vitro.

Authors:  M E Brawner; S G Mattern; M J Babcock; J Westpheling
Journal:  J Bacteriol       Date:  1997-05       Impact factor: 3.490

2.  The tcmVI region of the tetracenomycin C biosynthetic gene cluster of Streptomyces glaucescens encodes the tetracenomycin F1 monooxygenase, tetracenomycin F2 cyclase, and, most likely, a second cyclase.

Authors:  R G Summers; E Wendt-Pienkowski; H Motamedi; C R Hutchinson
Journal:  J Bacteriol       Date:  1993-12       Impact factor: 3.490

3.  Cloning and characterization of a polyketide synthase gene from Streptomyces fradiae Tü2717, which carries the genes for biosynthesis of the angucycline antibiotic urdamycin A and a gene probably involved in its oxygenation.

Authors:  H Decker; S Haag
Journal:  J Bacteriol       Date:  1995-11       Impact factor: 3.490

4.  Nucleotide sequences and heterologous expression of tcmG and tcmP, biosynthetic genes for tetracenomycin C in Streptomyces glaucescens.

Authors:  H Decker; H Motamedi; C R Hutchinson
Journal:  J Bacteriol       Date:  1993-06       Impact factor: 3.490
  4 in total

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