Literature DB >> 850306

P1 and P3 proteins of influenza virus are required for complementary RNA synthesis.

P Palese, M B Ritchey, J L Schulman.   

Abstract

Members of two temperature-sensitive (ts) mutant groups of influenza A/WSN virus defective in complementary RNA synthesis were analyzed with respect to the identity of their defective genes. RNA analysis of recombinants having a ts+ phenotype derived from the mutants and HK virus permitted the identification of RNA 1 and RNA 2 as the single defective gene in mutant groups I and III, respectively. Based on knowledge obtained by mapping the WSN virus genome, it then was possible to determine that biologically functional P3 protein (coded for by RNA 1) and P1 protein (RNA 2) are required for complementary RNA synthesis of influenza virus.

Entities:  

Mesh：

Substances：

Year:  1977        PMID： 850306      PMCID： PMC515659          DOI： 10.1128/JVI.21.3.1187-1195.1977

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  35 in total

1.  Methods for the quantitative estimation of N-acetylneuraminic acid and their application to hydrolysates of sialomucoids.

Authors:  D AMINOFF
Journal:  Biochem J       Date:  1961-11       Impact factor: 3.857

2.  Genetic composition of a high-yielding influenza A virus recombinant: a vaccine strain against "Swine" influenza.

Authors:  P Palese; M B Ritchey; J L Schulman; E D Kilbourne
Journal:  Science       Date:  1976-10-15       Impact factor: 47.728

3.  Selection and identification of influenza virus recombinants of defined genetic composition.

Authors:  J L Schulman; P Palese
Journal:  J Virol       Date:  1976-10       Impact factor: 5.103

4.  RNA pattern of 'swine' influenza virus isolated from man is similar to those of other swine influenza viruses.

Authors:  P Palese; J L Schulman
Journal:  Nature       Date:  1976-10-07       Impact factor: 49.962

5.  Temperature-sensitive virion transcriptase activity in mutants of WSN influenza virus.

Authors:  S L Mowshowitz; M Ueda
Journal:  Arch Virol       Date:  1976       Impact factor: 2.574

6.  Synthesis of influenza virus proteins in infected cells: translation of viral polypeptides, including three P polypeptides, from RNA produced by primary transcription.

Authors:  R A Lamb; P W Choppin
Journal:  Virology       Date:  1976-10-15       Impact factor: 3.616

7.  Polypeptides specified by the influenza virus genome I. Evidence for eight distinct gene products specified by fowl plague virus.

Authors:  S C Inglis; A R Carroll; R A Lamb; B W Mahy
Journal:  Virology       Date:  1976-10-15       Impact factor: 3.616

8.  Difference in protein patterns of influenza A viruses.

Authors:  M B Ritchey; P Palese; J L Schulman
Journal:  Virology       Date:  1977-01       Impact factor: 3.616

9.  Mapping of the influenza virus genome. II. Identification of the P1, P2, and P3 genes.

Authors:  P Palese; M B Ritchey; J L Schulman
Journal:  Virology       Date:  1977-01       Impact factor: 3.616

10.  Mapping of the influenza virus genome. III. Identification of genes coding for nucleoprotein, membrane protein, and nonstructural protein.

Authors:  M B Ritchey; P Palese; J L Schulman
Journal:  J Virol       Date:  1976-10       Impact factor: 5.103
View more
  22 in total

1.  Characterization of a temperature-sensitive mutant in the RNA polymerase PB2 subunit gene of influenza A/WSN/33 virus.

Authors:  K Yamanaka; N Ogasawara; M Ueda; H Yoshikawa; A Ishihama; K Nagata
Journal:  Arch Virol       Date:  1990       Impact factor: 2.574

2.  Expression of the three influenza virus polymerase proteins in a single cell allows growth complementation of viral mutants.

Authors:  M Krystal; R Li; D Lyles; G Pavlakis; P Palese
Journal:  Proc Natl Acad Sci U S A       Date:  1986-04       Impact factor: 11.205

3.  Anti-influenza virus activities of 4-substituted 2,4-dioxobutanoic acid inhibitors.

Authors:  J C Hastings; H Selnick; B Wolanski; J E Tomassini
Journal:  Antimicrob Agents Chemother       Date:  1996-05       Impact factor: 5.191

4.  Evolution of human influenza A viruses in nature: recombination contributes to genetic variation of H1N1 strains.

Authors:  J F Young; P Palese
Journal:  Proc Natl Acad Sci U S A       Date:  1979-12       Impact factor: 11.205

5.  Sequence relationships among defective interfering influenza viral RNAs.

Authors:  A R Davis; D P Nayak
Journal:  Proc Natl Acad Sci U S A       Date:  1979-07       Impact factor: 11.205

6.  Use of specific single stranded DNA probes cloned in M13 to study the RNA synthesis of four temperature-sensitive mutants of HK/68 influenza virus.

Authors:  F Thierry; O Danos
Journal:  Nucleic Acids Res       Date:  1982-05-11       Impact factor: 16.971

7.  Role of two of the influenza virus core P proteins in recognizing cap 1 structures (m7GpppNm) on RNAs and in initiating viral RNA transcription.

Authors:  I Ulmanen; B A Broni; R M Krug
Journal:  Proc Natl Acad Sci U S A       Date:  1981-12       Impact factor: 11.205

8.  Segments of influenza virus complementary RNA synthesized in vitro.

Authors:  S J Plotch; R M Krug
Journal:  J Virol       Date:  1978-02       Impact factor: 5.103

9.  Inhibition of cap (m7GpppXm)-dependent endonuclease of influenza virus by 4-substituted 2,4-dioxobutanoic acid compounds.

Authors:  J Tomassini; H Selnick; M E Davies; M E Armstrong; J Baldwin; M Bourgeois; J Hastings; D Hazuda; J Lewis; W McClements
Journal:  Antimicrob Agents Chemother       Date:  1994-12       Impact factor: 5.191

10.  Influenza virus temperature-sensitive cap (m7GpppNm)-dependent endonuclease.

Authors:  I Ulmanen; B Broni; R M Krug
Journal:  J Virol       Date:  1983-01       Impact factor: 5.103
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.