Literature DB >> 968486

Genetic composition of a high-yielding influenza A virus recombinant: a vaccine strain against "Swine" influenza.

P Palese, M B Ritchey, J L Schulman, E D Kilbourne.   

Abstract

Analysis of the RNA migration pattern of a high-yielding influenza virus recombinant, X-53, used in vaccine production, reveals that only the two genes coding for hemagglutinin and neuraminidase antigens were derived from the "swine" influenza virus parent. A/New Jersey/11/76, while six were acquired from the A/PR/8/34 (HON1) parent, donor of the high yield characteristic.

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Year:  1976        PMID： 968486     DOI： 10.1126/science.968486

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  10 in total

1.  P1 and P3 proteins of influenza virus are required for complementary RNA synthesis.

Authors:  P Palese; M B Ritchey; J L Schulman
Journal:  J Virol       Date:  1977-03       Impact factor: 5.103

2.  Detection of antibodies to influenza virus M protein by an enzyme-linked immunosorbent assay.

Authors:  M W Khan; D J Bucher; A K Koul; G Kalish; H Smith; E D Kilbourne
Journal:  J Clin Microbiol       Date:  1982-11       Impact factor: 5.948

3.  Common sequence at the 5' ends of the segmented RNA genomes of influenza A and B viruses.

Authors:  B Moss; J M Keith; A Gershowitz; M B Ritchey; P Palese
Journal:  J Virol       Date:  1978-01       Impact factor: 5.103

4.  Genetic dimorphism in influenza viruses: characterization of stably associated hemagglutinin mutants differing in antigenicity and biological properties.

Authors:  E D Kilbourne
Journal:  Proc Natl Acad Sci U S A       Date:  1978-12       Impact factor: 11.205

5.  Hemagglutinin of swine influenza virus: a single amino acid change pleiotropically affects viral antigenicity and replication.

Authors:  G W Both; C H Shi; E D Kilbourne
Journal:  Proc Natl Acad Sci U S A       Date:  1983-11       Impact factor: 11.205

6.  Matrix protein from influenza A virus and its role in cross-protection in mice.

Authors:  R G Webster; V S Hinshaw
Journal:  Infect Immun       Date:  1977-09       Impact factor: 3.441

7.  Monoclonal antibodies to the hemagglutinin Sa antigenic site of a/pr/8/34 influenza virus distinguish biologic mutants of swine influenza virus.

Authors:  E D Kilbourne; W Gerhard; C W Whitaker
Journal:  Proc Natl Acad Sci U S A       Date:  1983-10       Impact factor: 11.205

8.  An influenza A (H1N1) virus, closely related to swine influenza virus, responsible for a fatal case of human influenza.

Authors:  D E Wentworth; B L Thompson; X Xu; H L Regnery; A J Cooley; M W McGregor; N J Cox; V S Hinshaw
Journal:  J Virol       Date:  1994-04       Impact factor: 5.103

9.  Identification of the defective genes in three mutant groups of influenza virus.

Authors:  M B Ritchey; P Palese
Journal:  J Virol       Date:  1977-03       Impact factor: 5.103

10.  Immunization with 1976 swine H1N1- or 2009 pandemic H1N1-inactivated vaccines protects mice from a lethal 1918 influenza infection.

Authors:  Judith D Easterbrook; John C Kash; Zong-Mei Sheng; Li Qi; Jin Gao; Edwin D Kilbourne; Maryna C Eichelberger; Jeffery K Taubenberger
Journal:  Influenza Other Respir Viruses       Date:  2011-01-25       Impact factor: 4.380
  10 in total

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