| Literature DB >> 849378 |
Abstract
Large dietary intakes of yogurt are found to lower cholestermia in man. This effect is associated with a reduction of incorporation of radioacetate into serum cholesterol. The effect appears slowly and persists after intake of the yogurt stops suggesting that the mechanism involves the synthesis of a regulatory protein rather than an allosteric effect. The effective agent is postulated to be hydroxymethyl glutarate which inhibits the regulatory enzyme hydroxymethyl glutaryl CoA reductase (EC 1.1.1.3.4).Entities:
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Year: 1977 PMID： 849378 DOI： 10.1016/0021-9150(77)90086-7
Source DB: PubMed Journal: Atherosclerosis ISSN： 0021-9150 Impact factor: 5.162