Literature DB >> 8480532

In vitro effects of hyaluronan on prostaglandin E2 induction by interleukin-1 in rabbit articular chondrocytes.

M Akatsuka1, Y Yamamoto, K Tobetto, T Yasui, T Ando.   

Abstract

Effects of hyaluronan (HA) on the prostaglandin E2 (PGE2) production induced by recombinant human interleukin-1 beta (rhIL-1 beta) in rabbit articular chondrocytes were studied in vitro. The rhIL-1 beta-induced PGE2 production was dose-dependently inhibited by HA. HA with the highest molecular weight (M(r) = 2.0 x 10(6)) exhibited an inhibitory effect that was statistically more significant than the same polymer of lower molecular weights (M(r) = 1.0 x 10(6), 0.5 x 10(6)). This effect was observed in both young and adult rabbit articular chondrocytes. Since PGE2 has been implicated as a mediator of inflammatory joint diseases, our observations suggest that HA may elicit an anti-inflammatory effect by inhibiting PGE2 production.

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Year:  1993        PMID： 8480532     DOI： 10.1007/bf02027223

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  23 in total

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Journal:  Clin Exp Rheumatol       Date:  1990 May-Jun       Impact factor: 4.473

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Journal:  Nature       Date:  1980-08-28       Impact factor: 49.962

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Journal:  Biochem Biophys Res Commun       Date:  1989-12-29       Impact factor: 3.575

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Authors:  B P Toole
Journal:  Science       Date:  1973-04-20       Impact factor: 47.728

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Journal:  Eur J Immunol       Date:  1984-06       Impact factor: 5.532

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Authors:  M M Smith; P Ghosh
Journal:  Rheumatol Int       Date:  1987       Impact factor: 2.631

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Authors:  N C Rath; A L Oronsky; S S Kerwar
Journal:  Clin Immunol Immunopathol       Date:  1988-04

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Authors:  S Aihara; N Murakami; R Ishii; K Kariya; Y Azuma; K Hamada; J Umemoto; S Maeda
Journal:  Nihon Yakurigaku Zasshi       Date:  1992-10

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Authors:  J V Forrester; P C Wilkinson
Journal:  J Cell Sci       Date:  1981-04       Impact factor: 5.285
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  4 in total

1.  Suppressive effects of hyaluronan on MMP-1 and RANTES production from chondrocytes.

Authors:  Michiaki Tanaka; Kayo Masuko-Hongo; Tomohiro Kato; Kusuki Nishioka; Hiroshi Nakamura
Journal:  Rheumatol Int       Date:  2004-12-03       Impact factor: 2.631

Review 2.  Hyaluronic acid. A review of its pharmacology and use as a surgical aid in ophthalmology, and its therapeutic potential in joint disease and wound healing.

Authors:  K L Goa; P Benfield
Journal:  Drugs       Date:  1994-03       Impact factor: 9.546

3.  Intra-articular injections of high-molecular-weight hyaluronic acid have biphasic effects on joint inflammation and destruction in rat antigen-induced arthritis.

Authors:  Andreas Roth; Jürgen Mollenhauer; Andreas Wagner; Reneè Fuhrmann; Albrecht Straub; Rudolf A Venbrocks; Peter Petrow; Rolf Bräuer; Harald Schubert; Jörg Ozegowski; Gundela Peschel; Peter J Müller; Raimund W Kinne
Journal:  Arthritis Res Ther       Date:  2005-03-31       Impact factor: 5.156

4.  New Hyaluronic Acid from Plant Origin to Improve Joint Protection-An In Vitro Study.

Authors:  Rebecca Galla; Sara Ruga; Silvio Aprile; Sara Ferrari; Arianna Brovero; Giorgio Grosa; Claudio Molinari; Francesca Uberti
Journal:  Int J Mol Sci       Date:  2022-07-23       Impact factor: 6.208
  4 in total

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