Literature DB >> 2558648

Effects of recombinant interleukin-1 beta on phospholipase A2 activity, phospholipase A2 mRNA levels, and eicosanoid formation in rabbit chondrocytes.

J S Kerr1, T M Stevens, G L Davis, J A McLaughlin, R R Harris.   

Abstract

We have investigated the effects of recombinant interleukin-1 beta (rIL-1 beta) on phospholipase A2 activity (PLA2), PLA2 messenger RNA levels, and eicosanoid production in rabbit chondrocytes. Phospholipase A2 activity increased 5 fold with exposure to 1.6 x 10(-11) M rIL-1 beta for 20 hours. An mRNA specific for an extracellular PLA2 was detected by RNA blot hybridization after treatment of the cells with rIL-1 beta. Hydroxylated derivatives of arachidonic acid, including prostaglandins, leukotriene B4, 5-hydroxyeicosa 6E, 8Z, 11Z, 14Z-tetraenoic acid, 12-hydroxyeicosa 5Z, 8Z, 10E, 14Z-tetraenoic acid and 15-hydroxyeicosa 5Z, 8Z, 11Z, 13E-tetraenoic acid increased in cells after rIL-1 beta treatment.

Entities:  

Mesh：

Substances：

Year:  1989        PMID： 2558648     DOI： 10.1016/0006-291x(89)92712-5

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  11 in total

1.  Posttranscriptional effect of insulin-like growth factor-I on interleukin-1beta-induced type II-secreted phospholipase A2 gene expression in rabbit articular chondrocytes.

Authors:  C Jacques; G Béréziat; L Humbert; J L Olivier; M T Corvol; J Masliah; F Berenbaum
Journal:  J Clin Invest       Date:  1997-04-15       Impact factor: 14.808

2.  In vitro effects of hyaluronan on prostaglandin E2 induction by interleukin-1 in rabbit articular chondrocytes.

Authors:  M Akatsuka; Y Yamamoto; K Tobetto; T Yasui; T Ando
Journal:  Agents Actions       Date:  1993-01

3.  Cytokine-stimulated secretion of group II phospholipase A2 by rat mesangial cells. Its contribution to arachidonic acid release and prostaglandin synthesis by cultured rat glomerular cells.

Authors:  J Pfeilschifter; C Schalkwijk; V A Briner; H van den Bosch
Journal:  J Clin Invest       Date:  1993-11       Impact factor: 14.808

4.  Phospholipase A2 (PLA2) activity in bovine pulmonary artery endothelial cells.

Authors:  R Goodman; T M Stevens; L R Mantegna; P R Kidd; R R Harris; J S Kerr
Journal:  Agents Actions       Date:  1991-09

5.  Suppression of endothelin-1-induced mitogenic responses of human aortic smooth muscle cells by interleukin-1 beta.

Authors:  Y Fujitani; H Ninomiya; T Okada; Y Urade; T Masaki
Journal:  J Clin Invest       Date:  1995-06       Impact factor: 14.808

6.  Thrombin and activated protein C inhibit the expression of secretory group IIA phospholipase A(2) in the TNF-alpha-activated endothelial cells by EPCR and PAR-1 dependent mechanisms.

Authors:  Jong-Sup Bae; Alireza R Rezaie
Journal:  Thromb Res       Date:  2009-08-15       Impact factor: 3.944

7.  Effects of dexamethasone and transforming growth factor-beta 2 on group II phospholipase A2 mRNA and activity levels in interleukin 1 beta- and forskolin-stimulated mesangial cells.

Authors:  M J Vervoordeldonk; C G Schalkwijk; J Pfeilschifter; H van den Bosch
Journal:  Biochem J       Date:  1996-04-15       Impact factor: 3.857

8.  Ca(2+)-independent arachidonic acid release by vascular endothelium requires protein synthesis de novo.

Authors:  B J Buckley; A R Whorton
Journal:  Biochem J       Date:  1994-06-01       Impact factor: 3.857

9.  Contrasting effects of peroxisome-proliferator-activated receptor (PPAR)gamma agonists on membrane-associated prostaglandin E2 synthase-1 in IL-1beta-stimulated rat chondrocytes: evidence for PPARgamma-independent inhibition by 15-deoxy-Delta12,14prostaglandin J2.

Authors:  Arnaud Bianchi; David Moulin; Sylvie Sebillaud; Meriem Koufany; Marie-Madeleine Galteau; Patrick Netter; Bernard Terlain; Jean-Yves Jouzeau
Journal:  Arthritis Res Ther       Date:  2005-09-22       Impact factor: 5.156

10.  IL-1 and its role in rat carrageenan pleurisy.

Authors:  R Goodman; L R Mantegna; C L McAilister; E Bruin; R L Dowling; H George; W Feeser; B Freimark; M Lischwe; S Pick; R R Harris; J S Kerr
Journal:  Mediators Inflamm       Date:  1993       Impact factor: 4.711
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.