Literature DB >> 8474566

Heterogeneous distribution of functionally important amino acids in brain areas of adult and aging humans.

M Banay-Schwartz1, M Palkovits, A Lajtha.   

Abstract

The regional distribution of seven amino acids thought to have inhibitory neurotransmitter or neurotransmitter precursor function--GABA, glycine, taurine, serine, threonine, phenylalanine, and tyrosine--was determined in 52 discrete areas from brain of adult and old humans. Significant heterogeneity was found, with 3- to 16-fold differences in levels in the various regions analyzed. The patterns of distribution were somewhat different from those in the adult or old rat brain. Relatively few changes were seen in old brain. Heterogeneity in distribution has to be taken into account in assessing physiological changes in amino acid levels and metabolism.

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Year:  1993        PMID： 8474566     DOI： 10.1007/bf00967245

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  35 in total

1.  Effects of chronic administration of antipsychotic drugs on GABA and other amino acids in the mesolimbic area of rat brain.

Authors:  T L Perry; S Hansen; S J Kish
Journal:  Life Sci       Date:  1979-01-15       Impact factor: 5.037

2.  Brain amino acids in baboons with light-induced epilepsy.

Authors:  S Hansen; T L Perry; J A Wada; M Sokol
Journal:  Brain Res       Date:  1973-02-28       Impact factor: 3.252

3.  Isolated removal of hypothalamic or other brain nuclei of the rat.

Authors:  M Palkovits
Journal:  Brain Res       Date:  1973-09-14       Impact factor: 3.252

4.  Perinatal changes in the free amino acid pool of the brain in mice.

Authors:  A Lajtha; J Toth
Journal:  Brain Res       Date:  1973-05-30       Impact factor: 3.252

5.  Regional distribution and movement of amino acids in the brain.

Authors:  L Battistin; A Lajtha
Journal:  J Neurol Sci       Date:  1970-03       Impact factor: 3.181

6.  Amino acid content of epileptogenic human brain: focal versus surrounding regions.

Authors:  N M Van Gelder; A L Sherwin; T Rasmussen
Journal:  Brain Res       Date:  1972-05-26       Impact factor: 3.252

7.  Abnormalities in the levels of extracellular and tissue amino acids in the brain of the seizure-susceptible rat.

Authors:  A Lehmann
Journal:  Epilepsy Res       Date:  1989 Mar-Apr       Impact factor: 3.045

8.  Changes with aging in the levels of amino acids in rat CNS structural elements. II. Taurine and small neutral amino acids.

Authors:  M Banay-Schwartz; A Lajtha; M Palkovits
Journal:  Neurochem Res       Date:  1989-06       Impact factor: 3.996

9.  Amino acid neurotransmitter alterations in three sublines of Rb mice differing by their susceptibility to audiogenic seizures.

Authors:  S Simler; L Ciesielski; J Clement; P Mandel
Journal:  Neurochem Res       Date:  1990-07       Impact factor: 3.996

10.  Neuroexcitatory plasma amino acids are elevated in migraine.

Authors:  M D Ferrari; J Odink; K D Bos; M J Malessy; G W Bruyn
Journal:  Neurology       Date:  1990-10       Impact factor: 9.910
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  14 in total

1.  Levels of amino acids in 52 discrete areas of postmortem brain of adult and aged humans.

Authors:  M Banay-Schwartz; M Palkovits; A Lajtha
Journal:  Amino Acids       Date:  1993-06       Impact factor: 3.520

Review 2.  Taurine interaction with neurotransmitter receptors in the CNS: an update.

Authors:  Jan Albrecht; Arne Schousboe
Journal:  Neurochem Res       Date:  2005-12       Impact factor: 3.996

3.  Tissue correction for GABA-edited MRS: Considerations of voxel composition, tissue segmentation, and tissue relaxations.

Authors:  Ashley D Harris; Nicolaas A J Puts; Richard A E Edden
Journal:  J Magn Reson Imaging       Date:  2015-07-14       Impact factor: 4.813

4.  GABAA Receptors in the Mongolian Gerbil: a PET Study Using [18F]Flumazenil to Determine Receptor Binding in Young and Old Animals.

Authors:  M Kessler; M Mamach; R Beutelmann; M Lukacevic; S Eilert; P Bascuñana; A Fasel; F M Bengel; J P Bankstahl; T L Ross; G M Klump; G Berding
Journal:  Mol Imaging Biol       Date:  2020-04       Impact factor: 3.488

5.  In vivo magnetic resonance spectroscopy measurement of gray-matter and white-matter gamma-aminobutyric acid concentration in sensorimotor cortex using a motion-controlled MEGA point-resolved spectroscopy sequence.

Authors:  Pallab K Bhattacharyya; Micheal D Phillips; Lael A Stone; Mark J Lowe
Journal:  Magn Reson Imaging       Date:  2011-01-12       Impact factor: 2.546

6.  Is GABA neurotransmission enhanced in auditory thalamus relative to inferior colliculus?

Authors:  Rui Cai; Bopanna I Kalappa; Thomas J Brozoski; Lynne L Ling; Donald M Caspary
Journal:  J Neurophysiol       Date:  2013-10-23       Impact factor: 2.714

7.  Metabolome-wide association study of phenylalanine in plasma of common marmosets.

Authors:  Young-Mi Go; Douglas I Walker; Quinlyn A Soltow; Karan Uppal; Lynn M Wachtman; Fredrick H Strobel; Kurt Pennell; Daniel E L Promislow; Dean P Jones
Journal:  Amino Acids       Date:  2014-12-21       Impact factor: 3.520

8.  Elevated endogenous GABA concentration attenuates glutamate-glutamine cycling between neurons and astroglia.

Authors:  Jehoon Yang; Jun Shen
Journal:  J Neural Transm (Vienna)       Date:  2009-01-30       Impact factor: 3.575

9.  Regional difference in GABA levels between medial prefrontal and occipital cortices.

Authors:  Jan Willem van der Veen; Jun Shen
Journal:  J Magn Reson Imaging       Date:  2013-01-24       Impact factor: 4.813

10.  Alteration of protease levels in different brain areas of suicide victims.

Authors:  M Banay-Schwartz; T DeGuzman; G Faludi; A Lajtha; M Palkovits
Journal:  Neurochem Res       Date:  1998-07       Impact factor: 3.996
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