Jan Willem van der Veen1, Jun Shen. 1. Magnetic Resonance Spectroscopy Core Facility, National Institute of Mental Health, National Institutes of Health, MD 20892, USA. veen@nih.gov
Abstract
PURPOSE: To avoid the confounding effects of variations in tissue composition this study measured regional GABA differences using two voxels with the same tissue composition. MATERIALS AND METHODS: Eighteen healthy adult volunteers were scanned using a 3 Tesla GE clinical scanner with a J-coupling based editing sequence. Spectroscopy voxels were placed in the medial prefrontal (MPFC) and occipital cortex (OCC) with essentially the same gray and white matter fractions. RESULTS: A 16% (P = 0.0001) significantly higher GABA to creatine ratio was found in the OCC (0.1103 ± 0.0050) compared with the MPFC (0.0953 ± 0.0041). When normalized to tissue water, GABA concentrations in the OCC were 14% higher than in the MPFC. CONCLUSION: A difference in GABA concentration was found between the OCC and MPFC voxels in healthy subjects which is attributable to differences other than tissue composition.
PURPOSE: To avoid the confounding effects of variations in tissue composition this study measured regional GABA differences using two voxels with the same tissue composition. MATERIALS AND METHODS: Eighteen healthy adult volunteers were scanned using a 3 Tesla GE clinical scanner with a J-coupling based editing sequence. Spectroscopy voxels were placed in the medial prefrontal (MPFC) and occipital cortex (OCC) with essentially the same gray and white matter fractions. RESULTS: A 16% (P = 0.0001) significantly higher GABA to creatine ratio was found in the OCC (0.1103 ± 0.0050) compared with the MPFC (0.0953 ± 0.0041). When normalized to tissue water, GABA concentrations in the OCC were 14% higher than in the MPFC. CONCLUSION: A difference in GABA concentration was found between the OCC and MPFC voxels in healthy subjects which is attributable to differences other than tissue composition.
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