OBJECTIVES: The aim of this study was to examine the ability of exercise single-photon emission computed tomographic (SPECT) thallium imaging to identify high risk women with left main or three-vessel coronary artery disease using a stepwise discriminant analysis. BACKGROUND: Previous studies have used statistical methods to identify high risk men with coronary artery disease. Only limited data are available in women. METHODS: Exercise SPECT thallium imaging and coronary arteriography were performed for evaluation of chest pain in 243 women. Group 1 comprised 58 women with left main or three-vessel coronary disease and group 2 comprised 185 women with no or one- or two-vessel disease. Stepwise discriminant analysis was used to determine predictors of left main or three-vessel disease. RESULTS: On univariate analysis, women in group 1 were older (p < 0.03) and had a lower exercise work load (p < 0.02), lower exercise heart rate (p < 0.004), higher prevalence rate of diabetes mellitus (p < 0.0003) and more multivessel thallium abnormality (p < 0.0001) compared with women in group 2. On multivariate analysis, only multivessel thallium abnormality (F = 43) and exercise heart rate (F = 6) were independent predictors of left main or three-vessel coronary disease. A model based on these two variables separated the women into three risk groups: 99 patients with 9%, 70 patients with 23% and 74 patients with 45% prevalence of left main or three-vessel disease (p < 0.0001). CONCLUSIONS: High risk women with left main or three-vessel coronary disease can be identified by exercise SPECT thallium imaging.
OBJECTIVES: The aim of this study was to examine the ability of exercise single-photon emission computed tomographic (SPECT) thallium imaging to identify high risk women with left main or three-vessel coronary artery disease using a stepwise discriminant analysis. BACKGROUND: Previous studies have used statistical methods to identify high risk men with coronary artery disease. Only limited data are available in women. METHODS: Exercise SPECT thallium imaging and coronary arteriography were performed for evaluation of chest pain in 243 women. Group 1 comprised 58 women with left main or three-vessel coronary disease and group 2 comprised 185 women with no or one- or two-vessel disease. Stepwise discriminant analysis was used to determine predictors of left main or three-vessel disease. RESULTS: On univariate analysis, women in group 1 were older (p < 0.03) and had a lower exercise work load (p < 0.02), lower exercise heart rate (p < 0.004), higher prevalence rate of diabetes mellitus (p < 0.0003) and more multivessel thallium abnormality (p < 0.0001) compared with women in group 2. On multivariate analysis, only multivessel thallium abnormality (F = 43) and exercise heart rate (F = 6) were independent predictors of left main or three-vessel coronary disease. A model based on these two variables separated the women into three risk groups: 99 patients with 9%, 70 patients with 23% and 74 patients with 45% prevalence of left main or three-vessel disease (p < 0.0001). CONCLUSIONS: High risk women with left main or three-vessel coronary disease can be identified by exercise SPECT thallium imaging.
Authors: Fabian Bamberg; Ernst Klotz; Thomas Flohr; Alexander Becker; Christoph R Becker; Bernhard Schmidt; Bernd J Wintersperger; Maximilian F Reiser; Konstantin Nikolaou Journal: Eur Radiol Date: 2010-03-24 Impact factor: 5.315
Authors: Abdou Elhendy; Arend F L Schinkel; Jeroen J Bax; Ron T van Domburg; Roelf Valkema; Elena Biagini; Harm H Feringa; Don Poldermans Journal: J Nucl Cardiol Date: 2006-09 Impact factor: 5.952
Authors: Marcus Hacker; Johannes Rieber; Rupert Schmid; Christian Lafougere; Andreas Tausig; Karl Theisen; Volker Klaus; Reinhold Tiling Journal: J Nucl Cardiol Date: 2005 Nov-Dec Impact factor: 5.952