Literature DB >> 847230

Biosynthesis of prostaglandin D2. 1. Formation of prostaglandin D2 by human platelets.

O Oelz, R Oelz, H R Knapp, B J Sweetman, J A Oates.   

Abstract

Formation of prostaglandin D2 (PGD2) during the aggregation of platelets was determined, employing a specific bioassay. PGD2 was synthesized in human platelet rich plasma (PRP) in response to thrombin, collagen and epinephrine. Indomethacin pretreatment abolished the biosynthesis of PGD2. When thrombin treated PRP was incubated for different periods of time and denatured in the presence of SnCl2 to prevent the formation of PGD2 from endoperoxides during the extraction procedure, PGD2 formation was noted within the first minute of incubation and reached a peak level after 4 minutes. PGD2 from thrombin stimulated PRP was conclusively identified by gas chromatography-mass spectrometry. The formation of PGD2 during platelet aggregation could represent a mechanism of feedback inhibition of aggregation.

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Year:  1977        PMID： 847230     DOI： 10.1016/0090-6980(77)90004-1

Source DB:  PubMed          Journal:  Prostaglandins        ISSN： 0090-6980


  21 in total

1.  Niacin and biosynthesis of PGD₂by platelet COX-1 in mice and humans.

Authors:  Wen-Liang Song; Jane Stubbe; Emanuela Ricciotti; Naji Alamuddin; Salam Ibrahim; Irene Crichton; Maxwell Prempeh; John A Lawson; Robert L Wilensky; Lars Melholt Rasmussen; Ellen Puré; Garret A FitzGerald
Journal:  J Clin Invest       Date:  2012-03-12       Impact factor: 14.808

2.  Ionophores stimulate prostaglandin and thromboxane biosynthesis.

Authors:  H R Knapp; O Oelz; L J Roberts; B J Sweetman; J A Oates; P W Reed
Journal:  Proc Natl Acad Sci U S A       Date:  1977-10       Impact factor: 11.205

3.  Release of platelet-derived growth factor from human platelets by arachidonic acid.

Authors:  B L Linder; A Chernoff; K L Kaplan; D S Goodman
Journal:  Proc Natl Acad Sci U S A       Date:  1979-08       Impact factor: 11.205

Review 4.  The prostanoids in hemostasis and thrombosis: a review.

Authors:  J B Smith
Journal:  Am J Pathol       Date:  1980-06       Impact factor: 4.307

5.  Radioimmunological determination of prostaglandin D2 synthesis in human thrombocytes.

Authors:  H Anhut; B A Peskar; W Wachter; B Gräbling; B M Peskar
Journal:  Experientia       Date:  1978-11-15

6.  A convenient method for isolation and bioassay of prostaglandins E1, E2, F2 and D2 [proceedings].

Authors:  J P Denton; P Marples; A L Willis
Journal:  Br J Pharmacol       Date:  1978-06       Impact factor: 8.739

7.  Prostaglandin D2, a neuromodulator.

Authors:  T Shimizu; N Mizuno; T Amano; O Hayaishi
Journal:  Proc Natl Acad Sci U S A       Date:  1979-12       Impact factor: 11.205

8.  Arachidonic acid metabolites, hypertension and arteriosclerosis.

Authors:  P C Weber; W Siess; B Scherer; E Held; H Witzgall; R Lorenz
Journal:  Klin Wochenschr       Date:  1982-05-17

9.  Nasal challenge with cold, dry air results in release of inflammatory mediators. Possible mast cell involvement.

Authors:  A G Togias; R M Naclerio; D Proud; J E Fish; N F Adkinson; A Kagey-Sobotka; P S Norman; L M Lichtenstein
Journal:  J Clin Invest       Date:  1985-10       Impact factor: 14.808

10.  9-Deoxy-delta 9, delta 12-13,14-dihydroprostaglandin D2, a metabolite of prostaglandin D2 formed in human plasma.

Authors:  Y Kikawa; S Narumiya; M Fukushima; H Wakatsuka; O Hayaishi
Journal:  Proc Natl Acad Sci U S A       Date:  1984-03       Impact factor: 11.205
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