Literature DB >> 230503

Prostaglandin D2, a neuromodulator.

T Shimizu, N Mizuno, T Amano, O Hayaishi.   

Abstract

The distribution of prostaglandin D synthetase activity was determined in various tissues of rat by using the supernatant fraction (10,000 x g, 20 min) of the homogenates. The highest activity was found in brain, spinal cord, and alimentary tract. The activity was uniquitously distributed in all parts of brain, and the highest specific activity was found in hypothalamus and thalamus. Homogenates of two neuroblastoma cell lines were found to produce prostaglandin D2, whereas a glioma cell line was almost inactive. Prostaglandin D2 is a potent and specific activator of the adenylate cyclase system of cultured neuroblastoma cells, suggesting the possibility that it may act as a neuromodulator in the central nervous system.

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Year:  1979        PMID： 230503      PMCID： PMC411837          DOI： 10.1073/pnas.76.12.6231

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  25 in total

1.  Isomerization of prostaglandin H2 into prostaglandin D2 in the presence of serum albumin.

Authors:  M Hamberg; B B Fredholm
Journal:  Biochim Biophys Acta       Date:  1976-04-22

2.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

3.  An ultrasensitive method for the simultaneous determination of cyclic AMP and cyclic GMP in small-volume samples from blood and tissue.

Authors:  M Honma; T Satoh; J Takezawa; M Ui
Journal:  Biochem Med       Date:  1977-12

4.  Purification and characterisation of prostaglandin endoperoxide D-isomerase, a cytoplasmic, glutathione-requiring enzyme.

Authors:  E Christ-Hazelhof; D H Nugteren
Journal:  Biochim Biophys Acta       Date:  1979-01-29

5.  Prostaglandin D2 formation by malignant melanoma cells correlates inversely with cellular metastatic potential.

Authors:  F A Fitzpatrick; D A Stringfellow
Journal:  Proc Natl Acad Sci U S A       Date:  1979-04       Impact factor: 11.205

6.  Conversions of prostaglandin endoperoxides by glutathione-S-transferases and serum albumins.

Authors:  E Christ-Hazelhof; D H Nugteren; D A Van Dorp
Journal:  Biochim Biophys Acta       Date:  1976-12-20

7.  Metabolism of prostaglandin D2 in the monkey.

Authors:  C K Ellis; M D Smigel; J A Oates; O Oelz; B J Sweetman
Journal:  J Biol Chem       Date:  1979-05-25       Impact factor: 5.157

8.  Purification and properties of prostaglandin D synthetase from rat brain.

Authors:  T Shimizu; S Yamamoto; O Hayaishi
Journal:  J Biol Chem       Date:  1979-06-25       Impact factor: 5.157

9.  Cyclic nucleotides in central synaptic function.

Authors:  F E Bloom
Journal:  Fed Proc       Date:  1979-07

10.  Regional and species differences in endogenous prostaglandin biosynthesis by brain homogenates.

Authors:  M S Abdel-Halim; E Anggård
Journal:  Prostaglandins       Date:  1979-03
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  16 in total

1.  Role of the L-PGDS-PGD2-DP1 receptor axis in sleep regulation and neurologic outcomes.

Authors:  Abdullah Shafique Ahmad; Haneen Ottallah; Carolina B Maciel; Michael Strickland; Sylvain Doré
Journal:  Sleep       Date:  2019-06-11       Impact factor: 5.849

Review 2.  [Nerve cell clonal lines in culture--models for studying the molecular basis of neuropharmacological actions].

Authors:  H Herken
Journal:  Klin Wochenschr       Date:  1983-01-03

3.  Localization of prostaglandin D2 binding protein and NADP-linked 15-hydroxyprostaglandin D2 dehydrogenase in the Purkinje cells of miniature pig cerebellum.

Authors:  Y Watanabe; A Yamashita; H Tokumoto; O Hayaishi
Journal:  Proc Natl Acad Sci U S A       Date:  1983-07       Impact factor: 11.205

4.  Isolation and cultivation of mature oligodendroglial cells.

Authors:  H H Althaus; H Montz; V Neuhoff; P Schwartz
Journal:  Naturwissenschaften       Date:  1984-06

5.  Brain-type prostaglandin D synthetase occurs in the rat cochlea.

Authors:  M Tachibana; J Fex; Y Urade; O Hayaishi
Journal:  Proc Natl Acad Sci U S A       Date:  1987-11       Impact factor: 11.205

6.  Further studies on the mechanism of phosphorylase activation in rabbit liver in response to splanchnic nerve stimulation.

Authors:  T Shimazu; M Usami
Journal:  J Physiol       Date:  1982-08       Impact factor: 5.182

7.  Prostaglandin D2, a cerebral sleep-inducing substance in rats.

Authors:  R Ueno; K Honda; S Inoué; O Hayaishi
Journal:  Proc Natl Acad Sci U S A       Date:  1983-03       Impact factor: 11.205

8.  Effect of prostaglandin D2 on the femoral bone mineral density in ovariectomized rats.

Authors:  T Takagi; T Yamamoto; S Asano; H Tamaki
Journal:  Calcif Tissue Int       Date:  1993-06       Impact factor: 4.333

9.  Central nervous system effects of arachidonic acid, PGE2, PGF2 alpha, PGD2 and PGI2 on gastric secretion in the rat.

Authors:  J Puurunen
Journal:  Br J Pharmacol       Date:  1983-10       Impact factor: 8.739

10.  Inhibitory effects of prostaglandin D2 against the proliferation of human colon cancer cell lines and hepatic metastasis from colorectal cancer.

Authors:  T Yoshida; S Ohki; M Kanazawa; H Mizunuma; Y Kikuchi; H Satoh; Y Andoh; A Tsuchiya; R Abe
Journal:  Surg Today       Date:  1998       Impact factor: 2.549
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