Literature DB >> 8449883

A genetic analysis of various functions of the TyrR protein of Escherichia coli.

J Yang1, S Ganesan, J Sarsero, A J Pittard.   

Abstract

The TyrR protein is involved in both repression and activation of the genes of the TyrR regulon. Correction of an error in a previously published sequence has revealed a Cro-like helix-turn-helix DNA-binding domain near the carboxyl terminus. Site-directed mutagenesis in this region has generated a number of mutants that can no longer repress or activate. Deletions of amino acid residues 5 to 42 produced a protein that could repress but not activate. The central domain of TyrR contains an ATP-binding site and is homologous with the NtrC family of activator proteins. A mutation to site A of the ATP-binding site and other mutations in this region affect tyrosine-mediated repression but do not prevent activation or phenylalanine-mediated repression of aroG.

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Year:  1993        PMID： 8449883      PMCID： PMC203971          DOI： 10.1128/jb.175.6.1767-1776.1993

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  53 in total

1.  The phage 434 Cro/OR1 complex at 2.5 A resolution.

Authors:  A Mondragón; S C Harrison
Journal:  J Mol Biol       Date:  1991-05-20       Impact factor: 5.469

2.  Improved detection of helix-turn-helix DNA-binding motifs in protein sequences.

Authors:  I B Dodd; J B Egan
Journal:  Nucleic Acids Res       Date:  1990-09-11       Impact factor: 16.971

3.  Identification and sequence analysis of the gene encoding the transcriptional activator of the formate hydrogenlyase system of Escherichia coli.

Authors:  V Schlensog; A Böck
Journal:  Mol Microbiol       Date:  1990-08       Impact factor: 3.501

4.  Identification of the promoter, operator, and 5' and 3' ends of the mRNA of the Escherichia coli K-12 gene aroG.

Authors:  N Baseggio; W D Davies; B E Davidson
Journal:  J Bacteriol       Date:  1990-05       Impact factor: 3.490

5.  Conserved residues make similar contacts in two repressor-operator complexes.

Authors:  C O Pabo; A K Aggarwal; S R Jordan; L J Beamer; U R Obeysekare; S C Harrison
Journal:  Science       Date:  1990-03-09       Impact factor: 47.728

6.  FlbD of Caulobacter crescentus is a homologue of the NtrC (NRI) protein and activates sigma 54-dependent flagellar gene promoters.

Authors:  G Ramakrishnan; A Newton
Journal:  Proc Natl Acad Sci U S A       Date:  1990-03       Impact factor: 11.205

7.  The predicted protein product of a pathogenicity locus from Pseudomonas syringae pv. phaseolicola is homologous to a highly conserved domain of several procaryotic regulatory proteins.

Authors:  C Grimm; N J Panopoulos
Journal:  J Bacteriol       Date:  1989-09       Impact factor: 3.490

8.  Genetic regulation of formate hydrogenlyase of Escherichia coli: role of the fhlA gene product as a transcriptional activator for a new regulatory gene, fhlB.

Authors:  J A Maupin; K T Shanmugam
Journal:  J Bacteriol       Date:  1990-09       Impact factor: 3.490

9.  Three trans-acting regulatory functions control hydrogenase synthesis in Alcaligenes eutrophus.

Authors:  G Eberz; B Friedrich
Journal:  J Bacteriol       Date:  1991-03       Impact factor: 3.490

10.  Initial cloning and sequencing of hydHG, an operon homologous to ntrBC and regulating the labile hydrogenase activity in Escherichia coli K-12.

Authors:  K Stoker; W N Reijnders; L F Oltmann; A H Stouthamer
Journal:  J Bacteriol       Date:  1989-08       Impact factor: 3.490
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  30 in total

1.  Mechanism of repression of the aroP P2 promoter by the TyrR protein of Escherichia coli.

Authors:  J Yang; P Wang; A J Pittard
Journal:  J Bacteriol       Date:  1999-10       Impact factor: 3.490

2.  Specific contacts between residues in the DNA-binding domain of the TyrR protein and bases in the operator of the tyrP gene of Escherichia coli.

Authors:  J S Hwang; J Yang; A J Pittard
Journal:  J Bacteriol       Date:  1999-04       Impact factor: 3.490

3.  Analysis of elements involved in pseudoknot-dependent expression and regulation of the repA gene of an IncL/M plasmid.

Authors:  V Athanasopoulos; J Praszkier; A J Pittard
Journal:  J Bacteriol       Date:  1999-03       Impact factor: 3.490

4.  Solution structure of the DNA-binding domain of the TyrR protein of Haemophilus influenzae.

Authors:  Y Wang; S Zhao; R L Somerville; O Jardetzky
Journal:  Protein Sci       Date:  2001-03       Impact factor: 6.725

5.  A region of Bacillus subtilis CodY protein required for interaction with DNA.

Authors:  Pascale Joseph; Manoja Ratnayake-Lecamwasam; Abraham L Sonenshein
Journal:  J Bacteriol       Date:  2005-06       Impact factor: 3.490

6.  Promoters and transcripts associated with the aroP gene of Escherichia coli.

Authors:  P Wang; J Yang; A J Pittard
Journal:  J Bacteriol       Date:  1997-07       Impact factor: 3.490

7.  A bacterial ATP-dependent, enhancer binding protein that activates the housekeeping RNA polymerase.

Authors:  W C Bowman; R G Kranz
Journal:  Genes Dev       Date:  1998-06-15       Impact factor: 11.361

Review 8.  Linkage map of Escherichia coli K-12, edition 10: the traditional map.

Authors:  M K Berlyn
Journal:  Microbiol Mol Biol Rev       Date:  1998-09       Impact factor: 11.056

9.  Amino acid residues in the alpha-subunit C-terminal domain of Escherichia coli RNA polymerase involved in activation of transcription from the mtr promoter.

Authors:  J Yang; K Murakami; H Camakaris; N Fujita; A Ishihama; A J Pittard
Journal:  J Bacteriol       Date:  1997-10       Impact factor: 3.490

10.  Regulation of aroL expression by TyrR protein and Trp repressor in Escherichia coli K-12.

Authors:  B Lawley; A J Pittard
Journal:  J Bacteriol       Date:  1994-11       Impact factor: 3.490
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