BACKGROUND: Venous leg ulcers are a common cause of morbidity, but few predictive parameters exist that can be used to follow their progress. OBJECTIVE: We investigated the use of healing rate as a useful parameter in the treatment of venous ulceration. METHODS: Twenty-seven venous ulcers being treated with a standard regimen were evaluated. We calculated the initial (4-week) and overall healing rates using the Gilman method (delta A/p). RESULTS: The average initial healing rate for all ulcers combined, the healed group, and the nonhealing group was 0.069, 0.087, and -0.005 cm/wk, respectively. Similarly, the average overall healing rate for all ulcers combined, the healed group, and the nonhealing group was 0.062, 0.089, and -0.043 cm/wk, respectively. CONCLUSION: The initial healing rate (delta A/p(0-4)) may be an appropriate end point for clinical investigations comparing therapies for the treatment of chronic venous leg ulcers.
BACKGROUND:Venous leg ulcers are a common cause of morbidity, but few predictive parameters exist that can be used to follow their progress. OBJECTIVE: We investigated the use of healing rate as a useful parameter in the treatment of venous ulceration. METHODS: Twenty-seven venous ulcers being treated with a standard regimen were evaluated. We calculated the initial (4-week) and overall healing rates using the Gilman method (delta A/p). RESULTS: The average initial healing rate for all ulcers combined, the healed group, and the nonhealing group was 0.069, 0.087, and -0.005 cm/wk, respectively. Similarly, the average overall healing rate for all ulcers combined, the healed group, and the nonhealing group was 0.062, 0.089, and -0.043 cm/wk, respectively. CONCLUSION: The initial healing rate (delta A/p(0-4)) may be an appropriate end point for clinical investigations comparing therapies for the treatment of chronic venous leg ulcers.
Authors: Alejandra Vidal; Hugo Mendieta Zerón; Israel Giacaman; María Del Socorro Camarillo Romero; Sandra Parra López; Laura E Meza Trillo; David A Pérez Pérez; Miguel Concha; César Torres-Gallegos; Sandra L Orellana; Felipe Oyarzun-Ampuero; Ignacio Moreno-Villoslada Journal: J Am Coll Clin Wound Spec Date: 2016-07-29
Authors: Vincent Falanga; Roslyn Rivkah Isseroff; Athena M Soulika; Marco Romanelli; David Margolis; Suzanne Kapp; Mark Granick; Keith Harding Journal: Nat Rev Dis Primers Date: 2022-07-21 Impact factor: 65.038
Authors: Christine J Moffatt; Lynfa Edwards; Mark Collier; Terry Treadwell; Michael Miller; Laura Shafer; Gary Sibbald; Alain Brassard; Andrea McIntosh; Alex Reyzelman; Patricia Price; Stacia Merkel Kraus; Shelley-Ann Walters; Keith Harding Journal: Int Wound J Date: 2008-06 Impact factor: 3.315