Literature DB >> 8431357

Syrian hamster embryo cell lines useful for detecting transforming genes in mouse tumours: detection of transforming genes in X-ray-related mouse tumours.

H Sasai1, T Higashi, S Nakamori, J Miyoshi, F Suzuki, T Nomura, T Kakunaga.   

Abstract

The Syrian hamster embryo cell lines, SHOK and MC-1, were used as recipient cells for DNA transfection assay to detect transforming genes in experimental mouse tumours. A mouse repeat sequence was utilised to check whether each transformed focus included mouse genomic DNA in the Hamster background. We investigated five mouse tumours that are related to X-ray radiation, and detected activated c-K-ras, c-mos, and c-cot oncogenes which induced foci of hamster cells. These results show that SHOK and MC-1 cells have unique properties for detecting transforming genes in experimental mouse tumours.

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Year:  1993        PMID： 8431357      PMCID： PMC1968199          DOI： 10.1038/bjc.1993.50

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  25 in total

1.  Nucleotide sequence of the genome of a murine sarcoma virus.

Authors:  C Van Beveren; F van Straaten; J A Galleshaw; I M Verma
Journal:  Cell       Date:  1981-11       Impact factor: 41.582

2.  The p21 src genes of Harvey and Kirsten sarcoma viruses originate from divergent members of a family of normal vertebrate genes.

Authors:  R W Ellis; D Defeo; T Y Shih; M A Gonda; H A Young; N Tsuchida; D R Lowy; E M Scolnick
Journal:  Nature       Date:  1981-08-06       Impact factor: 49.962

3.  Parental exposure to x rays and chemicals induces heritable tumours and anomalies in mice.

Authors:  T Nomura
Journal:  Nature       Date:  1982-04-08       Impact factor: 49.962

4.  Molecular cloning of the Harvey sarcoma virus closed circular DNA intermediates: initial structural and biological characterization.

Authors:  G L Hager; E H Chang; H W Chan; C F Garon; M A Israel; M A Martin; E M Scolnick; D R Lowy
Journal:  J Virol       Date:  1979-09       Impact factor: 5.103

5.  Structure of the Abelson murine leukemia virus genome and the homologous cellular gene: studies with cloned viral DNA.

Authors:  S P Goff; E Gilboa; O N Witte; D Baltimore
Journal:  Cell       Date:  1980-12       Impact factor: 41.582

6.  Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene.

Authors:  L F Parada; C J Tabin; C Shih; R A Weinberg
Journal:  Nature       Date:  1982-06-10       Impact factor: 49.962

7.  Molecular cloning of the Fujinami sarcoma virus genome and its comparison with sequences of other related transforming viruses.

Authors:  M Shibuya; L H Wang; H Hanafusa
Journal:  J Virol       Date:  1982-06       Impact factor: 5.103

8.  Oncogenic activation of murine mos protein kinase by DNA rearrangement of its N-terminal coding region.

Authors:  T Ohuchi; Y Kurita; H Sasai; J Miyoshi; T Nomura; K Toyoshima
Journal:  Oncogene       Date:  1992-02       Impact factor: 9.867

9.  Structure and functions of the Kirsten murine sarcoma virus genome: molecular cloning of biologically active Kirsten murine sarcoma virus DNA.

Authors:  N Tsuchida; S Uesugi
Journal:  J Virol       Date:  1981-05       Impact factor: 5.103

10.  Molecular cloning and comparative analyses of the genomes of simian sarcoma virus and its associated helper virus.

Authors:  E P Gelmann; F Wong-Staal; R A Kramer; R C Gallo
Journal:  Proc Natl Acad Sci U S A       Date:  1981-06       Impact factor: 11.205
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