Literature DB >> 8429097

Detection of tumor necrosis factor-alpha-positive cells in cerebrospinal fluid of patients with HTLV-I-associated myelopathy.

S Nakamura1, I Nagano, M Yoshioka, S Shimazaki, J Onodera, K Kogure.   

Abstract

Tumor necrosis factor (TNF)-alpha-positive cells constituted 1.6-18% and 8.2-23.5% of the total number of cerebrospinal fluid cells from six of 12 patients with HTLV-I-associated myelopathy and in all samples obtained from inflammatory cases, respectively. However, in non-inflammatory cases no TNF-alpha-positive cells were detected. These results suggest that some of the infiltrating CSF cells produce TNF-alpha, which plays a role in host immune defenses against causative agents including HTLV-I and in lesion formation within the central nervous system in inflammatory diseases.

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Year:  1993        PMID： 8429097     DOI： 10.1016/0165-5728(93)90001-f

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  9 in total

1.  High circulating frequencies of tumor necrosis factor alpha- and interleukin-2-secreting human T-lymphotropic virus type 1 (HTLV-1)-specific CD4+ T cells in patients with HTLV-1-associated neurological disease.

Authors:  Peter K C Goon; Tadahiko Igakura; Emmanuel Hanon; Angelina J Mosley; Becca Asquith; Keith G Gould; Graham P Taylor; Jonathan N Weber; Charles R M Bangham
Journal:  J Virol       Date:  2003-09       Impact factor: 5.103

2.  A soluble form of tumour necrosis factor receptor in cerebrospinal fluid and serum of HTLV-I-associated myelopathy and other neurological diseases.

Authors:  M Puccioni-Sohler; P Rieckmann; B Kitze; P Lange; M Albrecht; K Felgenhauer
Journal:  J Neurol       Date:  1995-03       Impact factor: 4.849

Review 3.  Blood-brain barrier and retroviral infections.

Authors:  Florence Miller; Philippe V Afonso; Antoine Gessain; Pierre-Emmanuel Ceccaldi
Journal:  Virulence       Date:  2012-03-01       Impact factor: 5.882

4.  CSF CXCL10, CXCL9, and neopterin as candidate prognostic biomarkers for HTLV-1-associated myelopathy/tropical spastic paraparesis.

Authors:  Tomoo Sato; Ariella Coler-Reilly; Atae Utsunomiya; Natsumi Araya; Naoko Yagishita; Hitoshi Ando; Junji Yamauchi; Eisuke Inoue; Takahiko Ueno; Yasuhiro Hasegawa; Kusuki Nishioka; Toshihiro Nakajima; Steven Jacobson; Shuji Izumo; Yoshihisa Yamano
Journal:  PLoS Negl Trop Dis       Date:  2013-10-10

5.  Neurologic, clinical, and immunologic features in a cohort of HTLV-1 carriers with high proviral loads.

Authors:  Sheila N Ferraz; Gabriela F Costa; José Abraão Carneiro Neto; Thiago Hebert; Cassius J V de Oliveira; Mariele Guerra; Lívia M A Oliveira; Edgar M Carvalho
Journal:  J Neurovirol       Date:  2020-05-08       Impact factor: 2.643

6.  Following the Clues: Usefulness of Biomarkers of Neuroinflammation and Neurodegeneration in the Investigation of HTLV-1-Associated Myelopathy Progression.

Authors:  Flávia Dos Santos Souza; Nicole Lardini Freitas; Yago Côrtes Pinheiro Gomes; Rafael Carvalho Torres; Juliana Echevarria-Lima; Isaac Lima da Silva-Filho; Ana Claudia Celestino Bezerra Leite; Marco Antonio Sales Dantas de Lima; Marcus Tulius Teixeira da Silva; Abelardo de Queiroz Campos Araújo; Otávio Melo Espíndola
Journal:  Front Immunol       Date:  2021-10-26       Impact factor: 7.561

7.  Ascorbic acid has superior ex vivo antiproliferative, cell death-inducing and immunomodulatory effects over IFN-α in HTLV-1-associated myelopathy.

Authors:  Britta Moens; Daniele Decanine; Soraya Maria Menezes; Ricardo Khouri; Gilvanéia Silva-Santos; Giovanni Lopez; Carolina Alvarez; Michael Talledo; Eduardo Gotuzzo; Ramon de Almeida Kruschewsky; Bernardo Galvão-Castro; Anne-Mieke Vandamme; Johan Van Weyenbergh
Journal:  PLoS Negl Trop Dis       Date:  2012-07-24

8.  CD80+ and CD86+ B cells as biomarkers and possible therapeutic targets in HTLV-1 associated myelopathy/tropical spastic paraparesis and multiple sclerosis.

Authors:  Soraya Maria Menezes; Daniele Decanine; David Brassat; Ricardo Khouri; Saul V Schnitman; Ramon Kruschewsky; Giovanni López; Carolina Alvarez; Michael Talledo; Eduardo Gotuzzo; Anne-Mieke Vandamme; Bernardo Galvão-Castro; Roland Liblau; Johan Van Weyenbergh
Journal:  J Neuroinflammation       Date:  2014-01-29       Impact factor: 8.322

Review 9.  Immunovirological markers in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP).

Authors:  Yoshimi Enose-Akahata; Steven Jacobson
Journal:  Retrovirology       Date:  2019-11-29       Impact factor: 4.602
  9 in total

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