Literature DB >> 12915584

High circulating frequencies of tumor necrosis factor alpha- and interleukin-2-secreting human T-lymphotropic virus type 1 (HTLV-1)-specific CD4+ T cells in patients with HTLV-1-associated neurological disease.

Peter K C Goon1, Tadahiko Igakura, Emmanuel Hanon, Angelina J Mosley, Becca Asquith, Keith G Gould, Graham P Taylor, Jonathan N Weber, Charles R M Bangham.   

Abstract

Significantly higher frequencies of tumor necrosis factor alpha- and interleukin-2-secreting human T-lymphotropic virus type 1 (HTLV-1)-specific CD4(+) T cells were present in the peripheral blood mononuclear cells of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients than in those of asymptomatic carriers with similar provirus loads. The data suggest that HTLV-1-specific CD4(+) T cells play a role in the pathogenesis of HAM/TSP.

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Year:  2003        PMID： 12915584      PMCID： PMC187419          DOI： 10.1128/jvi.77.17.9716-9722.2003

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  46 in total

1.  Single-cytokine-producing CD4 memory cells predominate in type 1 and type 2 immunity.

Authors:  A Y Karulin; M D Hesse; M Tary-Lehmann; P V Lehmann
Journal:  J Immunol       Date:  2000-02-15       Impact factor: 5.422

2.  Abundant tax protein expression in CD4+ T cells infected with human T-cell lymphotropic virus type I (HTLV-I) is prevented by cytotoxic T lymphocytes.

Authors:  E Hanon; S Hall; G P Taylor; M Saito; R Davis; Y Tanaka; K Usuku; M Osame; J N Weber; C R Bangham
Journal:  Blood       Date:  2000-02-15       Impact factor: 22.113

3.  Cytotoxic T-cell abundance and virus load in human immunodeficiency virus type 1 and human T-cell leukaemia virus type 1.

Authors:  D Wodarz; S E Hall; K Usuku; M Osame; G S Ogg; A J McMichael; M A Nowak; C R Bangham
Journal:  Proc Biol Sci       Date:  2001-06-22       Impact factor: 5.349

4.  Do T cells cause HTLV-1-associated disease?: a taxing problem.

Authors:  S Daenke; C R Bangham
Journal:  Clin Exp Immunol       Date:  1994-05       Impact factor: 4.330

5.  Broad, intense anti-human immunodeficiency virus (HIV) ex vivo CD8(+) responses in HIV type 1-infected patients: comparison with anti-Epstein-Barr virus responses and changes during antiretroviral therapy.

Authors:  M Dalod; M Dupuis; J C Deschemin; D Sicard; D Salmon; J F Delfraissy; A Venet; M Sinet; J G Guillet
Journal:  J Virol       Date:  1999-09       Impact factor: 5.103

6.  The transactivator gene of human T-cell leukemia virus type I is more variable within and between healthy carriers than patients with tropical spastic paraparesis.

Authors:  S Niewiesk; S Daenke; C E Parker; G Taylor; J Weber; S Nightingale; C R Bangham
Journal:  J Virol       Date:  1994-10       Impact factor: 5.103

7.  Single cell analysis of cytokine gene coexpression during CD4+ T-cell phenotype development.

Authors:  R P Bucy; L Karr; G Q Huang; J Li; D Carter; K Honjo; J A Lemons; K M Murphy; C T Weaver
Journal:  Proc Natl Acad Sci U S A       Date:  1995-08-01       Impact factor: 11.205

8.  Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation.

Authors:  M Cella; D Scheidegger; K Palmer-Lehmann; P Lane; A Lanzavecchia; G Alber
Journal:  J Exp Med       Date:  1996-08-01       Impact factor: 14.307

9.  High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10.

Authors:  F Koch; U Stanzl; P Jennewein; K Janke; C Heufler; E Kämpgen; N Romani; G Schuler
Journal:  J Exp Med       Date:  1996-08-01       Impact factor: 14.307

10.  Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.

Authors:  F Sallusto; A Lanzavecchia
Journal:  J Exp Med       Date:  1994-04-01       Impact factor: 14.307
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  29 in total

Review 1.  Interference with immune function by HTLV-1.

Authors:  P K C Goon; C R M Bangham
Journal:  Clin Exp Immunol       Date:  2004-08       Impact factor: 4.330

Review 2.  Neuroimmunity of HTLV-I Infection.

Authors:  Eiji Matsuura; Yoshihisa Yamano; Steven Jacobson
Journal:  J Neuroimmune Pharmacol       Date:  2010-05-02       Impact factor: 4.147

3.  Helminthic infection and the risk of neurologic disease progression in HTLV-1.

Authors:  Michael A Sundberg; Davi Costa; Gloria Orge; Néviton M Castro; André Muniz; Marshall J Glesby; Edgar M Carvalho
Journal:  J Clin Virol       Date:  2012-01-10       Impact factor: 3.168

Review 4.  Human T-lymphotropic virus type 1 (HTLV-1): persistence and immune control.

Authors:  Charles R M Bangham
Journal:  Int J Hematol       Date:  2003-11       Impact factor: 2.490

5.  High expression of CD244 and SAP regulated CD8 T cell responses of patients with HTLV-I associated neurologic disease.

Authors:  Yoshimi Enose-Akahata; Eiji Matsuura; Unsong Oh; Steven Jacobson
Journal:  PLoS Pathog       Date:  2009-12-04       Impact factor: 6.823

6.  Immunogenetics and the Pathological Mechanisms of Human T-Cell Leukemia VirusType 1- (HTLV-1-)Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP).

Authors:  Mineki Saito
Journal:  Interdiscip Perspect Infect Dis       Date:  2010-02-10

7.  HTLV-1 modifies the clinical and immunological response to schistosomiasis.

Authors:  A F Porto; S B Santos; L Alcantara; J B Guerreiro; J Passos; T Gonzalez; F Neva; D Gonzalez; J L Ho; E M Carvalho
Journal:  Clin Exp Immunol       Date:  2004-08       Impact factor: 4.330

8.  Ex vivo analysis of human T lymphotropic virus type 1-specific CD4+ cells by use of a major histocompatibility complex class II tetramer composed of a neurological disease-susceptibility allele and its immunodominant peptide.

Authors:  Hirohisa Nose; Ryuji Kubota; Nilufer P Seth; Peter K Goon; Yuetsu Tanaka; Shuji Izumo; Koichiro Usuku; Yoshiro Ohara; Kai W Wucherpfennig; Charles R M Bangham; Mitsuhiro Osame; Mineki Saito
Journal:  J Infect Dis       Date:  2007-12-15       Impact factor: 5.226

9.  The Predominant CD4+ Th1 Cytokine Elicited to Chlamydia trachomatis Infection in Women Is Tumor Necrosis Factor Alpha and Not Interferon Gamma.

Authors:  Stephen J Jordan; Kanupriya Gupta; Brian M O Ogendi; Rakesh K Bakshi; Richa Kapil; Christen G Press; Steffanie Sabbaj; Jeannette Y Lee; William M Geisler
Journal:  Clin Vaccine Immunol       Date:  2017-04-05

10.  Ascorbic acid has superior ex vivo antiproliferative, cell death-inducing and immunomodulatory effects over IFN-α in HTLV-1-associated myelopathy.

Authors:  Britta Moens; Daniele Decanine; Soraya Maria Menezes; Ricardo Khouri; Gilvanéia Silva-Santos; Giovanni Lopez; Carolina Alvarez; Michael Talledo; Eduardo Gotuzzo; Ramon de Almeida Kruschewsky; Bernardo Galvão-Castro; Anne-Mieke Vandamme; Johan Van Weyenbergh
Journal:  PLoS Negl Trop Dis       Date:  2012-07-24
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