Dietary fish oil alters rat milk composition and liver and brain fatty acid composition of fetal and neonatal rats.

This study was performed to determine the effects of dietary fish oil rich in docosahexaenoic acid [22:6(n-3)] on the milk composition of maternal rats and tissue fatty acid composition of fetal and neonatal rats. The fatty acid composition of dam's milk was affected by the dietary fat. The level of 22: 6(n-3) in the milk of dams fed the fish oil-containing diet was severalfold higher than that of dams fed the diet that did not contain fish oil, and the levels of 22: 6(n-3) in the phospholipids of the livers and brains of fetuses and pups of the fish oil-fed group were higher than those in fetuses and pups of the group that did not receive fish oil. These findings suggest that a high level of 22:6(n-3) in the livers and brains of fetal and neonatal rats can be achieved by intake of fish oil by the dams.