Literature DB >> 8407547

Suppression of rabbit VX-2 subcutaneous tumor growth by gadolinium neutron capture therapy.

Y Akine1, N Tokita, K Tokuuye, M Satoh, H Churei, C Le Pechoux, T Kobayashi, K Kanda.   

Abstract

VX-2 tumors growing in hind legs of New Zealand White rabbits (n = 4) were exposed to thermal neutrons for 40 min (2.1 x 10(12) neutrons cm-2) while one of two hind leg tumors of each rabbit was infused continuously with meglumine gadopentetate through a branch of the left femoral artery. The contralateral (uninfused) tumors served as controls. Although no differential distribution of gadolinium was achieved between the tumor and its adjacent normal tissue, the gadolinium concentration in the infused tumor was approximately 5-6 fold higher than that in the contralateral tumor. Growth of gadolinium-infused tumors was significantly inhibited compared to that of control tumors (P < 0.05) between the 16th and 23rd days after treatment.

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Year:  1993        PMID： 8407547      PMCID： PMC5919270          DOI： 10.1111/j.1349-7006.1993.tb02055.x

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


  10 in total

1.  Radiation effect of gadolinium-neutron capture reactions on the survival of Chinese hamster cells.

Authors:  Y Akine; N Tokita; T Matsumoto; H Oyama; S Egawa; O Aizawa
Journal:  Strahlenther Onkol       Date:  1990-12       Impact factor: 3.621

2.  [Simplified intraarterial infusion and angiographic method for rabbit VX-2 hind limb tumor via the saphenous artery].

Authors:  Y Homma; H Suda; K Ebe; M Hatanaka; T Nakanishi
Journal:  Nihon Igaku Hoshasen Gakkai Zasshi       Date:  1990-04-25

3.  Evaluation of gadolinium-157 as a neutron capture therapy agent.

Authors:  R M Brugger; J A Shih
Journal:  Strahlenther Onkol       Date:  1989 Feb-Mar       Impact factor: 3.621

4.  Inactivation of mammalian cells after disintegration of 3H or 125I in cell DNA at -196 degrees C.

Authors:  H J Burki; R Roots; L E Feinendegen; V P Bond
Journal:  Int J Radiat Biol Relat Stud Phys Chem Med       Date:  1973-10

5.  Induction of double-strand breaks following neutron capture by DNA-bound 157Gd.

Authors:  R F Martin; G D'Cunha; M Pardee; B J Allen
Journal:  Int J Radiat Biol       Date:  1988-08       Impact factor: 2.694

6.  Electron-equivalent dose for the effect of gadolinium neutron capture therapy on the growth of subcutaneously-inoculated Ehrlich tumor cells in mice.

Authors:  Y Akine; N Tokita; K Tokuuye; M Satoh; T Kobayashi; K Kanda
Journal:  Jpn J Clin Oncol       Date:  1993-06       Impact factor: 3.019

7.  Neutron-capture therapy of murine ascites tumor with gadolinium-containing microcapsules.

Authors:  Y Akine; N Tokita; K Tokuuye; M Satoh; Y Fukumori; H Tokumitsu; R Kanamori; T Kobayashi; K Kanda
Journal:  J Cancer Res Clin Oncol       Date:  1992       Impact factor: 4.553

8.  Gadolinium neutron capture therapy for brain tumors: a computer study.

Authors:  J T Masiakowski; J L Horton; L J Peters
Journal:  Med Phys       Date:  1992 Sep-Oct       Impact factor: 4.071

9.  Transport calculations of depth-dose distributions for gadolinium neutron capture therapy.

Authors:  T Matsumoto
Journal:  Phys Med Biol       Date:  1992-01       Impact factor: 3.609

10.  THE PROGRESSION TO CARCINOMA OF VIRUS-INDUCED RABBIT PAPILLOMAS (SHOPE).

Authors:  P Rous; J W Beard
Journal:  J Exp Med       Date:  1935-09-30       Impact factor: 14.307
  10 in total
  3 in total

1.  Chitosan-gadopentetic acid complex nanoparticles for gadolinium neutron-capture therapy of cancer: preparation by novel emulsion-droplet coalescence technique and characterization.

Authors:  H Tokumitsu; H Ichikawa; Y Fukumori
Journal:  Pharm Res       Date:  1999-12       Impact factor: 4.200

2.  Comparison of gadobenate dimeglumine and gadopentetate dimeglumine: a study of MR imaging and inductively coupled plasma atomic emission spectroscopy in rat brain tumors.

Authors:  Tian Zhang; Akira Matsumura; Tetsuya Yamamoto; Fumiyo Yoshida; Tadao Nose; Nobuhiro Shimojo
Journal:  AJNR Am J Neuroradiol       Date:  2002-01       Impact factor: 3.825

3.  Gd@C82 metallofullerenes for neutron capture therapy-fullerene solubilization by poly(ethylene glycol)-block-poly(2-(N, N-diethylamino)ethyl methacrylate) and resultant efficacy in vitro.

Authors:  Yukichi Horiguchi; Shinpei Kudo; Yukio Nagasaki
Journal:  Sci Technol Adv Mater       Date:  2011-07-07       Impact factor: 8.090
  3 in total

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