Literature DB >> 2900277

Induction of double-strand breaks following neutron capture by DNA-bound 157Gd.

R F Martin1, G D'Cunha, M Pardee, B J Allen.   

Abstract

Irradiation of plasmid DNA/Gd3+ mixtures with thermal neutrons induces DNA double-strand breaks (dsb). However, the extent of breakage is markedly reduced by sequestering the Gd3+ from DNA by addition of EDTA. Since the 157Gd neutron capture event involves some internal conversion, we suggest that the DNA dsb induction results from Auger electron emission.

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Year:  1988        PMID: 2900277     DOI: 10.1080/09553008814551641

Source DB:  PubMed          Journal:  Int J Radiat Biol        ISSN: 0955-3002            Impact factor:   2.694


  7 in total

1.  Liquid crystal dispersions of DNA complexes with gadolinium as a possible basis for neutron-trapping therapy.

Authors:  Yu M Yevdokimov; V I Salyanov; O V Kondrashina; M A Lagutina; A A Gasanov; V N Nikiforov; V I Borshchevskii; K A Dembo; I V Reshetov
Journal:  Dokl Biochem Biophys       Date:  2005 May-Jun       Impact factor: 0.788

2.  Chitosan-gadopentetic acid complex nanoparticles for gadolinium neutron-capture therapy of cancer: preparation by novel emulsion-droplet coalescence technique and characterization.

Authors:  H Tokumitsu; H Ichikawa; Y Fukumori
Journal:  Pharm Res       Date:  1999-12       Impact factor: 4.200

Review 3.  Physical, dosimetric and clinical aspects and delivery systems in neutron capture therapy.

Authors:  Bagher Farhood; Hadi Samadian; Mahdi Ghorbani; Seyed Salman Zakariaee; Courtney Knaup
Journal:  Rep Pract Oncol Radiother       Date:  2018-08-01

Review 4.  Cutting edge rare earth radiometals: prospects for cancer theranostics.

Authors:  Alexander W E Sadler; Leena Hogan; Benjamin Fraser; Louis M Rendina
Journal:  EJNMMI Radiopharm Chem       Date:  2022-08-26

5.  Neutron-capture therapy of murine ascites tumor with gadolinium-containing microcapsules.

Authors:  Y Akine; N Tokita; K Tokuuye; M Satoh; Y Fukumori; H Tokumitsu; R Kanamori; T Kobayashi; K Kanda
Journal:  J Cancer Res Clin Oncol       Date:  1992       Impact factor: 4.553

6.  In vivo evaluation of the effects of combined boron and gadolinium neutron capture therapy in mouse models.

Authors:  Woonghee Lee; Kyung Won Kim; Jeong Eun Lim; Swarbhanu Sarkar; Jung Young Kim; Yongmin Chang; Jeongsoo Yoo
Journal:  Sci Rep       Date:  2022-08-03       Impact factor: 4.996

7.  Suppression of rabbit VX-2 subcutaneous tumor growth by gadolinium neutron capture therapy.

Authors:  Y Akine; N Tokita; K Tokuuye; M Satoh; H Churei; C Le Pechoux; T Kobayashi; K Kanda
Journal:  Jpn J Cancer Res       Date:  1993-08
  7 in total

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