Literature DB >> 8406801

Infection of murine macrophages with Toxoplasma gondii is associated with release of transforming growth factor beta and downregulation of expression of tumor necrosis factor receptors.

L E Bermudez1, G Covaro, J Remington.   

Abstract

Toxoplasma gondii is capable of invading and multiplying within murine peritoneal macrophages. Previous studies have shown that treatment of macrophage monolayers with recombinant gamma interferon but not tumor necrosis factor (TNF) is associated with intracellular killing of T. gondii by macrophages. Furthermore, infection of macrophages with T. gondii prevents their stimulation for mycobactericidal activity by TNF. Since transforming growth factor beta (TGF-beta) is known to suppress a number of functions in macrophages, we investigated the influence of infection with T. gondii on macrophage TNF receptors and on production of TGF-beta. Infection with T. gondii was associated with increased production of TGF-beta and downregulation of TNF receptors. This effect was observed early after infection and was partially inhibited by anti-TGF-beta 1 antibody.

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Year:  1993        PMID： 8406801      PMCID： PMC281134          DOI： 10.1128/iai.61.10.4126-4130.1993

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  22 in total

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Authors:  M A Orellana; Y Suzuki; F Araujo; J S Remington
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Authors:  C M Black; L E Bermudez; L S Young; J S Remington
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10.  Regulation of Trypanosoma cruzi infections in vitro and in vivo by transforming growth factor beta (TGF-beta).

Authors:  J S Silva; D R Twardzik; S G Reed
Journal:  J Exp Med       Date:  1991-09-01       Impact factor: 14.307
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  18 in total

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Review 2.  Subversion of innate and adaptive immune responses by Toxoplasma gondii.

Authors:  Christine Lang; Uwe Gross; Carsten G K Lüder
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5.  Down-regulation of MHC class II molecules and inability to up-regulate class I molecules in murine macrophages after infection with Toxoplasma gondii.

Authors:  C G Lüder; T Lang; B Beuerle; U Gross
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7.  Astrocytic TGF-β signaling limits inflammation and reduces neuronal damage during central nervous system Toxoplasma infection.

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8.  Toxoplasma gondii activates hypoxia-inducible factor (HIF) by stabilizing the HIF-1alpha subunit via type I activin-like receptor kinase receptor signaling.

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9.  Transforming growth factor-beta 1 primes macrophages for enhanced expression of the nitric oxide synthase gene for nitric oxide-dependent cytotoxicity against Entamoeba histolytica.

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10.  Production of TNF-alpha, IL-6 and TGF-beta, and expression of receptors for TNF-alpha and IL-6, during murine Mycobacterium avium infection.

Authors:  J Champsi; L S Young; L E Bermudez
Journal:  Immunology       Date:  1995-04       Impact factor: 7.397
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