Literature DB >> 1908831

Role of beta interferon in resistance to Toxoplasma gondii infection.

M A Orellana1, Y Suzuki, F Araujo, J S Remington.   

Abstract

The role of recombinant murine beta interferon (rMuIFN-beta) and recombinant human IFN-beta (rHuIFN-beta) in resistance to Toxoplasma gondii was examined. rMuIFN-beta protected mice against a lethal infection with the parasite. The protective effect appeared to depend on the concomitant release of gamma interferon. rMuIFN-beta did not activate murine peritoneal macrophages to inhibit or kill T. gondii whether used alone or in combination with lipopolysaccharide (LPS). rHuIFN-beta did not activate human monocyte-derived macrophages to inhibit or kill T. gondii when 5-day-old monocyte-derived macrophages were used. In contrast, significant killing of T. gondii was noted when 10-day-old monocyte-derived macrophages were used. The addition of LPS enhanced this effect. These results revealed a role for IFN-beta in the mechanisms of defense against T. gondii and suggest its potential use in the treatment of toxoplasmosis in humans.

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Year:  1991        PMID： 1908831      PMCID： PMC258166          DOI： 10.1128/iai.59.9.3287-3290.1991

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  19 in total

1.  Beta interferon inhibits Toxoplasma gondii growth in human monocyte-derived macrophages.

Authors:  J L Schmitz; J M Carlin; E C Borden; G I Byrne
Journal:  Infect Immun       Date:  1989-10       Impact factor: 3.441

2.  Antigen presentation by Toxoplasma gondii-infected cells to CD4+ proliferative T cells and CD8+ cytotoxic cells.

Authors:  A Yano; F Aosai; M Ohta; H Hasekura; K Sugane; S Hayashi
Journal:  J Parasitol       Date:  1989-06       Impact factor: 1.276

3.  Induction of antigen-specific parasiticidal cytotoxic T cell splenocytes by a major membrane protein (P30) of Toxoplasma gondii.

Authors:  I A Khan; K A Smith; L H Kasper
Journal:  J Immunol       Date:  1988-11-15       Impact factor: 5.422

4.  In vitro and in vivo antiviral action of an interferon-like substance induced by Toxoplasma gondii.

Authors:  M M Freshman; T C Merigan; J S Remington; I E Brownlee
Journal:  Proc Soc Exp Biol Med       Date:  1966-12

5.  Natural killer activity in cloned cytotoxic T lymphocytes: regulation by interleukin 2, interferon, and specific antigen.

Authors:  C G Brooks; M Holscher; D Urdal
Journal:  J Immunol       Date:  1985-08       Impact factor: 5.422

6.  Antibacterial activity of recombinant murine beta interferon.

Authors:  T Fujiki; A Tanaka
Journal:  Infect Immun       Date:  1988-03       Impact factor: 3.441

7.  Relationship between the production of interferon-alpha/beta and interferon-gamma during acute toxoplasmosis.

Authors:  B Diez; A Galdeano; R Nicolas; R Cisterna
Journal:  Parasitology       Date:  1989-08       Impact factor: 3.234

8.  Role of tryptophan degradation in respiratory burst-independent antimicrobial activity of gamma interferon-stimulated human macrophages.

Authors:  H W Murray; A Szuro-Sudol; D Wellner; M J Oca; A M Granger; D M Libby; C D Rothermel; B Y Rubin
Journal:  Infect Immun       Date:  1989-03       Impact factor: 3.441

9.  Synergistic inhibition of human marrow granulocyte-macrophage progenitor cells by prostaglandin E and recombinant interferon-alpha, -beta, and -gamma and an effect mediated by tumor necrosis factor.

Authors:  L M Pelus; O G Ottmann; K H Nocka
Journal:  J Immunol       Date:  1988-01-15       Impact factor: 5.422

10.  Interferon-gamma: the major mediator of resistance against Toxoplasma gondii.

Authors:  Y Suzuki; M A Orellana; R D Schreiber; J S Remington
Journal:  Science       Date:  1988-04-22       Impact factor: 47.728
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  15 in total

1.  Mechanisms of interferon-induced inhibition of Toxoplasma gondii replication in human retinal pigment epithelial cells.

Authors:  C N Nagineni; K Pardhasaradhi; M C Martins; B Detrick; J J Hooks
Journal:  Infect Immun       Date:  1996-10       Impact factor: 3.441

2.  Infection of murine macrophages with Toxoplasma gondii is associated with release of transforming growth factor beta and downregulation of expression of tumor necrosis factor receptors.

Authors:  L E Bermudez; G Covaro; J Remington
Journal:  Infect Immun       Date:  1993-10       Impact factor: 3.441

3.  Production of interferons in human placental trophoblast subpopulations and their possible roles in pregnancy.

Authors:  G Aboagye-Mathiesen; F D Tóth; M Zdravkovic; P Ebbesen
Journal:  Clin Diagn Lab Immunol       Date:  1994-11

4.  The GRA15 protein from Toxoplasma gondii enhances host defense responses by activating the interferon stimulator STING.

Authors:  Peiyan Wang; Siji Li; Yingchi Zhao; Baohuan Zhang; Yunfei Li; Shengde Liu; Hongqiang Du; Lili Cao; Meiling Ou; Xiaohong Ye; Peng Li; Xiang Gao; Penghua Wang; Chunxia Jing; Feng Shao; Guang Yang; Fuping You
Journal:  J Biol Chem       Date:  2019-08-15       Impact factor: 5.157

5.  Toxoplasma gondii effector TgIST blocks type I interferon signaling to promote infection.

Authors:  Sumit K Matta; Philipp Olias; Zhou Huang; Qiuling Wang; Eugene Park; Wayne M Yokoyama; L David Sibley
Journal:  Proc Natl Acad Sci U S A       Date:  2019-08-14       Impact factor: 11.205

6.  Involvement of beta interferon in enhancing inducible nitric oxide synthase production and antimicrobial activity of Burkholderia pseudomallei-infected macrophages.

Authors:  P Utaisincharoen; N Anuntagool; K Limposuwan; P Chaisuriya; S Sirisinha
Journal:  Infect Immun       Date:  2003-06       Impact factor: 3.441

Review 7.  Protozoan Parasites and Type I IFNs.

Authors:  Sasha Silva-Barrios; Simona Stäger
Journal:  Front Immunol       Date:  2017-01-19       Impact factor: 7.561

8.  Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases.

Authors:  Akul Singhania; Christine M Graham; Leona Gabryšová; Lúcia Moreira-Teixeira; Evangelos Stavropoulos; Jonathan M Pitt; Probir Chakravarty; Annika Warnatsch; William J Branchett; Laura Conejero; Jing-Wen Lin; Sophia Davidson; Mark S Wilson; Gregory Bancroft; Jean Langhorne; Eva Frickel; Abdul K Sesay; Simon L Priestnall; Eleanor Herbert; Marianna Ioannou; Qian Wang; Ian R Humphreys; Jonathan Dodd; Peter J M Openshaw; Katrin D Mayer-Barber; Dragana Jankovic; Alan Sher; Clare M Lloyd; Nicole Baldwin; Damien Chaussabel; Venizelos Papayannopoulos; Andreas Wack; Jacques F Banchereau; Virginia M Pascual; Anne O'Garra
Journal:  Nat Commun       Date:  2019-06-28       Impact factor: 14.919

9.  Transcriptional analysis of murine macrophages infected with different Toxoplasma strains identifies novel regulation of host signaling pathways.

Authors:  Mariane B Melo; Quynh P Nguyen; Cynthia Cordeiro; Musa A Hassan; Ninghan Yang; Renée McKell; Emily E Rosowski; Lindsay Julien; Vincent Butty; Marie-Laure Dardé; Daniel Ajzenberg; Katherine Fitzgerald; Lucy H Young; Jeroen P J Saeij
Journal:  PLoS Pathog       Date:  2013-12-19       Impact factor: 6.823

10.  TLR4 abrogates the Th1 immune response through IRF1 and IFN-β to prevent immunopathology during L. infantum infection.

Authors:  Laís Amorim Sacramento; Luciana Benevides; Sandra Regina Maruyama; Lucas Tavares; Kiyoshi Ferreira Fukutani; Marcela Francozo; Tim Sparwasser; Fernando Queiroz Cunha; Roque Pacheco Almeida; João Santana da Silva; Vanessa Carregaro
Journal:  PLoS Pathog       Date:  2020-03-25       Impact factor: 6.823
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