OBJECTIVE: To confirm insulinoma as the cause of hypoglycemia in a patient with NIDDM and determine the frequency of the co-occurrence of these two conditions. RESEARCH DESIGN AND METHODS: The patient underwent an in-hospital prolonged fast (< or = 72 h), according to standard protocol, and an ultrasound examination of the pancreas. All cases of histologically confirmed insulinoma at this institution over the period of 1927-1992 were reviewed to determine the prevalence of pre-existent diabetes mellitus. RESULTS: After 10 h of fasting, plasma glucose was low (1.89 mM); plasma insulin (258 pM) and C-peptide (1.39 nM) were elevated in the absence of sulfonylurea in the plasma. An insulinoma detected by ultrasonography was removed surgically with subsequent reoccurrence of insulin-requiring diabetes. Among 313 cases of insulinoma confirmed at this institution, this patient is the only one with pre-existent diabetes mellitus. CONCLUSIONS: Insulinoma occurs extraordinarily rarely in patients with pre-existing NIDDM.
OBJECTIVE: To confirm insulinoma as the cause of hypoglycemia in a patient with NIDDM and determine the frequency of the co-occurrence of these two conditions. RESEARCH DESIGN AND METHODS: The patient underwent an in-hospital prolonged fast (< or = 72 h), according to standard protocol, and an ultrasound examination of the pancreas. All cases of histologically confirmed insulinoma at this institution over the period of 1927-1992 were reviewed to determine the prevalence of pre-existent diabetes mellitus. RESULTS: After 10 h of fasting, plasma glucose was low (1.89 mM); plasma insulin (258 pM) and C-peptide (1.39 nM) were elevated in the absence of sulfonylurea in the plasma. An insulinoma detected by ultrasonography was removed surgically with subsequent reoccurrence of insulin-requiring diabetes. Among 313 cases of insulinoma confirmed at this institution, this patient is the only one with pre-existent diabetes mellitus. CONCLUSIONS:Insulinoma occurs extraordinarily rarely in patients with pre-existing NIDDM.
Authors: M Filippella; M V Davì; G Doveri; E Lillaz; A Ciccarelli; E Massimetti; M Toaiari; M Falconi; A Colao; A Faggiano Journal: J Endocrinol Invest Date: 2010-04-12 Impact factor: 4.256
Authors: A Raffel; M Anlauf; S-B Hosch; M Krausch; T Henopp; J Bauersfeld; R Klofat; D Bach; C-F Eisenberger; G Kloppel; W-T Knoefel Journal: World J Gastroenterol Date: 2006-11-28 Impact factor: 5.742
Authors: M Toaiari; M V Davì; L Dalle Carbonare; L Boninsegna; C Castellani; M Falconi; G Francia Journal: J Endocrinol Invest Date: 2013-04-18 Impact factor: 4.256