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Literature DB >> 17131493

Hyperinsulinemic hypoglycemia due to adult nesidioblastosis in insulin-dependent diabetes.

A Raffel¹, M Anlauf, S-B Hosch, M Krausch, T Henopp, J Bauersfeld, R Klofat, D Bach, C-F Eisenberger, G Kloppel, W-T Knoefel.

Abstract

In neonates, persistent hyperinsulinemic hypoglycemia (PHH) is associated with nesidioblastosis. In adults, PHH is usually caused by solitary benign insulinomas. We report on an adult patient who suffered from insulin-dependent diabetes mellitus, and subsequently developed PHH caused by diffuse nesidioblastosis. Mutations of the MEN1 and Mody (2/3) genes were ruled out. Preoperative diagnostic procedures, the histopathological criteria and the surgical treatment options of adult nesidioblastosis are discussed. So far only one similar case of adult nesidioblastosis subsequent to diabetes mellitus II has been reported in the literature. In case of conversion of diabetes into hyperinsulinemic hypoglycemia syndrome, nesidioblastosis in addition to insulinoma should be considered.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2006 PMID： 17131493 PMCID： PMC4087792 DOI： 10.3748/wjg.v12.i44.7221

Source DB: PubMed Journal: World J Gastroenterol ISSN： 1007-9327 Impact factor: 5.742

22 in total

1. Fasting hypoglycemia in adults.

Authors: S S Fajans; J C Floyd
Journal: N Engl J Med Date: 1976-04-01 Impact factor: 91.245

2. Beta cell nesidioblastosis in idiopathic hypoglycemia of infancy.

Authors: W C Yakovac; L Baker; K Hummeler
Journal: J Pediatr Date: 1971-08 Impact factor: 4.406

3. Effects of novel maturity-onset diabetes of the young (MODY)-associated mutations on glucokinase activity and protein stability.

Authors: María Galán; Olivier Vincent; Isabel Roncero; Sharona Azriel; Pedro Boix-Pallares; Elías Delgado-Alvarez; Francisco Díaz-Cadórniga; Enrique Blázquez; María-Angeles Navas
Journal: Biochem J Date: 2006-01-01 Impact factor: 3.857

Review 4. The molecular basis of persistent hyperinsulinemic hypoglycemia of infancy and its pathologic substrates.

Authors: A Reinecke-Lüthge; F Koschoreck; G Klöppel
Journal: Virchows Arch Date: 2000-01 Impact factor: 4.064

5. Noninsulinoma pancreatogenous hypoglycemia syndrome: an update in 10 surgically treated patients.

Authors: G B Thompson; F J Service; J C Andrews; R V Lloyd; N Natt; J A van Heerden; C S Grant
Journal: Surgery Date: 2000-12 Impact factor: 3.982

6. Hypoglycemia and endogenous hyperinsulinism complicating diabetes mellitus. Application of the C-peptide assay to diagnosis and therapy.

Authors: R Sandler; D L Horwitz; A H Rubenstein; H Kuzuya
Journal: Am J Med Date: 1975-11 Impact factor: 4.965

7. Hypoglycaemia from islet cell hyperplasia and nesidioblastosis in a patient with type 2 diabetes mellitus--a case report.

Authors: Y C Kon; K C Loh; S P Chew; D Wong; W M Yap; Y S Lee; C H Low
Journal: Ann Acad Med Singapore Date: 2000-09 Impact factor: 2.473

8. The focal form of persistent hyperinsulinemic hypoglycemia of infancy: morphological and molecular studies show structural and functional differences with insulinoma.

Authors: Christine Sempoux; Yves Guiot; Karin Dahan; Pierre Moulin; Martine Stevens; Virginie Lambot; Pascale de Lonlay; Jean-Christophe Fournet; Claudine Junien; Francis Jaubert; Claire Nihoul-Fekete; Jean-Marie Saudubray; Jacques Rahier
Journal: Diabetes Date: 2003-03 Impact factor: 9.461

9. Insulin determination by specific and unspecific immunoassays in patients with insulinoma evaluated by the arterial stimulation and venous sampling test.

Authors: Peter Wiesli; Michael Brändle; Thomas Pfammatter; Jürgen Zapf; Giatgen A Spinas; Christoph Schmid
Journal: Eur J Endocrinol Date: 2004-07 Impact factor: 6.664

Hyperinsulinemic hypoglycemia due to adult nesidioblastosis in insulin-dependent diabetes.

1. Fasting hypoglycemia in adults.

2. Beta cell nesidioblastosis in idiopathic hypoglycemia of infancy.

3. Effects of novel maturity-onset diabetes of the young (MODY)-associated mutations on glucokinase activity and protein stability.

Review 4. The molecular basis of persistent hyperinsulinemic hypoglycemia of infancy and its pathologic substrates.

5. Noninsulinoma pancreatogenous hypoglycemia syndrome: an update in 10 surgically treated patients.

6. Hypoglycemia and endogenous hyperinsulinism complicating diabetes mellitus. Application of the C-peptide assay to diagnosis and therapy.

7. Hypoglycaemia from islet cell hyperplasia and nesidioblastosis in a patient with type 2 diabetes mellitus--a case report.

8. The focal form of persistent hyperinsulinemic hypoglycemia of infancy: morphological and molecular studies show structural and functional differences with insulinoma.

9. Insulin determination by specific and unspecific immunoassays in patients with insulinoma evaluated by the arterial stimulation and venous sampling test.

10. Pitfalls in endosonographic imaging of suspected insulinomas: pancreatic nodules of unknown dignity.

Review 1. Occult sporadic insulinoma: localization and surgical strategy.

2. An unusual cause of hypoglycemia in a middle-aged female after bariatric surgery.

3. Nesidioblastosis and Pancreatic Non-functioning Islet Cell Tumor in an Adult with Type 2 Diabetes Mellitus.

4. NESIDIOBLASTOSIS IN AN ADULT WITH SHORT GUT SYNDROME AND TYPE 2 DIABETES.