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Literature DB >> 8403511

Transforming growth factor-beta (TGF-beta) in human milk.

S Saito¹, M Yoshida, M Ichijo, S Ishizaka, T Tsujii.

Abstract

The amount of TGF-beta contained in human whey was studied by the colony formation of NRK47F cells. It was noted that a factor inducing colony formation did exist in human whey, and its action was neutralized when anti-TGF-beta antibodies were introduced. This suggests that TGF-beta does exist in human whey. In colostrum, the total amount of TGF-beta was 1365.7 +/- 242.9 ng/ml, of which the active form comprised 728.1 +/- 248.7 ng/ml (n = 21). In late milk, the total TGF-beta was 952.5 +/- 212.6 ng/ml, with an active form of 178.7 +/- 157.3 ng/ml. Thus human milk contains a large amount of active TGF-beta. Furthermore, it was revealed by the reverse transcriptase polymerase chain reaction that mRNAs coding TGF-beta 1 and TGF-beta 2 exist in human milk cells. These results suggest that both TGF-beta 1 and TGF-beta 2 exist in human milk.

Entities: Gene Species

Mesh：

Substances：

Year: 1993 PMID： 8403511 PMCID： PMC1534356 DOI： 10.1111/j.1365-2249.1993.tb06004.x

Source DB: PubMed Journal: Clin Exp Immunol ISSN： 0009-9104 Impact factor: 4.330

31 in total

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Journal: Proc Natl Acad Sci U S A Date: 1978-08 Impact factor: 11.205

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Journal: Mol Reprod Dev Date: 1992-06 Impact factor: 2.609

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Journal: Nature Date: 1985 Aug 22-28 Impact factor: 49.962

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Authors: S K Sinha; A A Yunis
Journal: Biochem Biophys Res Commun Date: 1983-07-29 Impact factor: 3.575

30 in total

Review 1. Effect of breast milk and weaning on epithelial growth of the small intestine in humans.

Authors: A G Cummins; F M Thompson
Journal: Gut Date: 2002-11 Impact factor: 23.059

Review 2. Enterocytes: active cells in tolerance to food and microbial antigens in the gut.

Authors: N Miron; V Cristea
Journal: Clin Exp Immunol Date: 2012-03 Impact factor: 4.330

Review 3. Host factors in amniotic fluid and breast milk that contribute to gut maturation.

Authors: Carol L Wagner; Sarah N Taylor; Donna Johnson
Journal: Clin Rev Allergy Immunol Date: 2008-04 Impact factor: 8.667

4. Milk cytokines and subclinical breast inflammation in Tanzanian women: effects of dietary red palm oil or sunflower oil supplementation.

Authors: S M Filteau; G Lietz; G Mulokozi; S Bilotta; C J Henry; A M Tomkins
Journal: Immunology Date: 1999-08 Impact factor: 7.397

5. Oral administration of transforming growth factor-β1 (TGF-β1) protects the immature gut from injury via Smad protein-dependent suppression of epithelial nuclear factor κB (NF-κB) signaling and proinflammatory cytokine production.

Authors: Sheng-Ru Shiou; Yueyue Yu; Yuee Guo; Maria Westerhoff; Lei Lu; Elaine O Petrof; Jun Sun; Erika C Claud
Journal: J Biol Chem Date: 2013-10-15 Impact factor: 5.157

6. Elevated plasma transforming growth factor-beta 1 levels in breast cancer patients decrease after surgical removal of the tumor.

Authors: F M Kong; M S Anscher; T Murase; B D Abbott; J D Iglehart; R L Jirtle
Journal: Ann Surg Date: 1995-08 Impact factor: 12.969