| Literature DB >> 3861940 |
R Derynck, J A Jarrett, E Y Chen, D H Eaton, J R Bell, R K Assoian, A B Roberts, M B Sporn, D V Goeddel.
Abstract
The partial amino-acid sequence of purified human transforming growth factor-beta (TGF-beta) was used to identify a series of cDNA clones encoding the protein. The cDNA sequence indicates that the 112-amino acid monomeric form of the natural TGF-beta homodimer is derived proteolytically from a much longer precursor polypeptide which may be secreted. TGF-beta messenger RNA is synthesized in various normal and transformed cells.Entities:
Mesh：
Substances：
Year: 1985 PMID： 3861940 DOI： 10.1038/316701a0
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962